Research Overview
Transport regulation in oogenesis
The coordinator Klar (green) is present on the nuclear envelope in ovaries (DNA in blue).
Guo et al.,2005
Several of the regulators involved in droplet transport are also expressed during oogenesis. Our genetic analysis indicates that here they serve roles in a number of processes, from trafficking of secretory vesicles to the positioning of the oocyte nucleus. We focus on the function of Klar: Oocytes express four different Klar isoforms, and our analysis indicates that these isoforms have distinct biological properties. We are now testing whether different isoforms are dedicated to distinct transport processes or uniquely regulate a common set of transport processes or both. The long-term goal of this analysis is to understand how cells can adapt a small set of motors and regulators to uniquely control a wide range of transport processes.
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