Our laboratory investigates the cellular stress response pathways that determine cell fate after exposure to cytotoxic and mutagenic damaging agents. To study the diverse processes involved in the stress response, we use an integrated approach combining biochemistry, molecular biology and cell physiology in mammalian tissue culture systems and genetic mouse models. Through this approach, we have discovered novel targets and functions for proteins involved in DNA repair, RNA modification and programmed cell death. Since DNA damage poses a significant threat to genome integrity and cellular viability, a greater understanding of the molecular mechanisms that respond to DNA damage will provide critical insight into multiple aspects of human health, including cancer prevention and therapy, degenerative disorders and aging.
Our research encompasses: