Dragony Fu

Assistant Professor

Contact Information:

University of Rochester
Department of Biology

River Campus Box 270211
Rochester, New York 14627-0211

Hutchison 333 (office)
Hutchison 331 (lab)

(585) 276-3346 (office)
(585) 275-0348 (lab)

Research Overview


Our laboratory investigates the cellular stress response pathways that determine cell fate after exposure to cytotoxic and mutagenic damaging agents. To study the diverse processes involved in the stress response, we use an integrated approach combining biochemistry, molecular biology and cell physiology in mammalian tissue culture systems and genetic mouse models. Through this approach, we have discovered novel targets and functions for proteins involved in DNA repair, RNA modification and programmed cell death. Since DNA damage poses a significant threat to genome integrity and cellular viability, a greater understanding of the molecular mechanisms that respond to DNA damage will provide critical insight into multiple aspects of human health, including cancer prevention and therapy, degenerative disorders and aging.

Our research encompasses:

  • Nucleic acid repair and modification
  • Regulation of protein translation in response to genotoxic stress
  • Programmed necrotic cell death induced by DNA damage

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Selected Publications