Lipid droplets store neutral lipids when resources are abundant; when resources are scares, stored lipids can be used for the production of energy and as a source of metabolites during “lean” times. As a consequence, our studies illuminate not only how microtubule motors are deployed in a controlled manner in the cell, but may also shed light on lipid homeostasis and energy metabolism. We recently discovered a new biological role for lipid droplets as sites of regulated protein sequestration, a role with broad implications for cell and developmental biology.
Our research is very visual and generates striking images; see, for example, the cover of the September 30th (2003) issue of Current Biology and our entry into the Drosophila Image Award 2007 competition.
For more details on our research, please check out the links below: