Entrepreneur-Ready Technologies

Entrepreneur-Ready Technologies has been introduced to help highlight some of the University of Rochester’s most promising inventions. We believe the technologies and innovations described below have significant commercial potential. Some of these items could fit nicely into a company’s existing intellectual property portfolio to enhance a product line or help launch a new one. Others represent platform technologies that could constitute the foundation of a new startup company. In either case, we invite you to peruse the following which will be updated periodically with new featured patents. If anything is of interest, please contact the Office of Technology Transfer or submit your contact information.

Optical Detection of Nano-Particles

Particles as small as 5 nanometers are detected optically in a nanoscale channel in a micro-fluidic system.

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Photodynamic Therapy

An instrument for real-time determination of photodynamic therapy dosimetry in vivo, employing measurements of fluorescence emission spectra corrected for effects of dynamic tissue optical properties using white light diffuse reflectance.

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High Molecular Weight Hyaluronic Acid

Cell lines from the skin of naked mole rats produces high molecular weight hyaluronic acid (HA), which has a market for of about $1billion for injections for arthritis patients and in anti-wrinkle cosmetics.

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Robust Array-Capable Optical Biosensor

Bio-molecules are detected by the change in reflectivity of polarized light from a micro-array silicon chip surface, for measurement of biomolecular interaction rates and the detection of pathogens.

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Detection of Chromosomal Translocations

Using novel array-based technology, this will create a rapid, easy and accurate detection of chromosomal translocations associated with cancer and other diseases.

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Highly Fluorescent Near-IR Quantum Dots

These semiconductor nano-clusters are highly fluorescent in the near infra red, of extremely small diameter (< 2 nm), and easily fabricated.

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Video Game for Increased Math Skills

An action-packed video game developed to train mathematics skills in non-verbal number sense and by following established factors for brain plasticity and learning.

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Hybridization-Based Unquenching of DNA Hairpins on Au Surfaces

Identifies the use of olignucleitide sequences, which consist of natural genes and contain a number of bases, making the technique more arrayable and practical.

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Biopsy Device for Lumpectomy Excisions

Optical inspection system to assist a pathologist in determining the location of the guidewire in a surgical lumpectomy specimen.

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Targeting, Silencing or Modifying RNA Transcripts

Allows for the creation of molecules that can selectively target RNA molecules that benefit from modifications to splice sites to make them perform in a proper function.

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Ultrasound Measurement of Tissue Stiffness

This method provides a measurement of tissue shear modulus (stiffness), which is a known marker of disease, but is not visible in conventional ultra-sound.

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Verified Voice Communication

The concept enables embedding data in a low bit rate channel, such as a voice channel over radio. The data “watermark” is hidden and robust, and can be used to identify and authenticate the source of the signal.

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New Recombinant Activated Protein C

A new method to treat sepsis, a major cause of death in intensive-care units, by binding to neutrophil integrins at high affinity at sites of infections and reducing the neutrophil migration during sepsis.

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Titanium Aluminide Metal Forming

Manufacturing method for high temperature, wear-resistant components of intermetallics, such as TiAl, for engine valves and other uses.

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Devices and Method for Improved Diagnosis of GERD Related Respiratory Disease

Measurements of simultaneous continuous pulse oximetry and esophageal pH monitoring to serve as an improved diagnostic test for patients with respiratory disease associated with gastroesophageal reflux.

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Mesenchymal Stem Cell Populations to Treat Bone Disorders

Stem cell technologies that work synergistically to treat orthopedic diseases and injuries, such as trauma, spinal fusion, tissue engineering and bone defects.

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Shape Memory Polymers

Shape memory polymers with the unique property of a tunable shape recovery rate. This allows bulky synthesized objects to be deformed into smaller, pliable states and then returned at a controlled rate to the original shape.

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Low Noise Infra-Red Detector

A novel semiconductor structure comprising of a unipolar barrier layer inserted to block unwanted surface current, but pass bulk current, in IR detector arrays and other devices.

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Ultra-High Resolution Ophthalmoscope

A microscope for viewing the retina at the back of the eye at the cellular level to detect disease at a very early stage before blindness occurs.

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Audio Data-Hiding

Enables the insertion and recovery of hidden data in audio files through manipulation of the relative phase of harmonically related components of a host audio signal.

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Color Image Bar Code

This color image encoding and data extraction technique provides the equivalent of a high data capacity 2D bar code in a tone-adjusted image for a more attractive printed data element.

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Video Game Treatment for Lazy Eye

An action video game with a split screen or head-mounted display is used to treat “lazy eye” (amblyopia). The game is fun and can be played at home.

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Membrane for Intermediate Temperature Fuel Cells

Thin, dense composite membranes of c-axis aligned hydroxyapatite single crystals. The gas-tight and proton-conducting membranes enable fuel cells to operate in the 300 - 600 degrees Celsius range.

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Acoustical Measurement During a Music Performance

This method for acoustics measurement can provide analysis in real time of an on-going performance through low-energy test signals that are masked by the music.

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