March 31, 2015 –
Time: 7 – 8 pm
Location: Gowen Room, Wilson Commons
Purpose: Town Hall provides Grads and UnderGrads the opportunity to hear from President Seligman the State of the College and to ask any questions.
April 7, 2015 –
Department of Biomedical Engineering Ph.D. Thesis Defense Seminar
“Enzymatically-responsive Poly(ethylene glycol) Hydrogels for the Controlled Delivery of Therapeutic Peptides”
Presented by: Amy H. Van Hove
Supervised by: Prof. Danielle Benoit
Tuesday, April 7, 2015 at 8:30 AM
Robert B. Goergen Hall
Sloan Auditorium, Room 101
Therapeutic angiogenesis holds great potential for treatment of ischemic tissues and in tissue engineering, where insufficient vascularization limits construct size, complexity, and anastomosis with host vasculature. However, no FDA approved treatments exist to robustly enhance vascularization within ischemic tissue. Many pro-angiogenic approaches have been developed, often via delivery of angiogenic proteins or peptides. Peptides typically mimic the bioactivity of larger proteins or growth factors, and offer advantages over traditional protein delivery. However, like proteins, peptides suffer from rapid clearance and poor pharmacokinetics when delivered systemically. Therefore, a poly(ethylene glycol) (PEG) hydrogel-based platform technology was developed to control and sustain peptide drug release via matrix metalloproteinase (MMP) activity.
In vitro bioactivity testing identified three peptides (Qk (from Vascular Endothelial Growth Factor), SPARC113, and SPARC118 (from Secreted Protein Acidic and Rich in Cysteine)) that retained bioactivity in their expected released forms (e.g., with residual amino acids left by MMP substrates after cleavage). Incorporation of these peptides into hydrogels flanked by MMP-degradable substrates successfully produced hydrogels with enzymatically-responsive hydrogel degradation and peptide release behaviors. Qk, SPARC113, and SPARC118-releasing hydrogels were confirmed to release bioactive components in vitro after MMP-mediated degradation. Further investigation revealed key peptide drug properties, specifically size and hydrophobicity, control the rate of hydrogel degradation and peptide release. When implanted subcutaneously, SPARC113 and SPARC118-releasing hydrogels both significantly increased vascular ingrowth compared to controls without significantly affecting vessel size. As the longitudinal availability of VEGF has been shown critical for bioactivity, alternate hydrogels were developed to provide temporal control over enzymatically-responsive release of Qk, the VEGF peptide mimic. Modifying the MMP-degradable linker used to tether Qk to hydrogels provided temporal control over enzymatically-responsive peptide release in vitro and in vivo. Qk was confirmed to be bioactive as released, but hydrogels releasing Qk failed to induce significant vascularization in vivo, likely due to use of non-degradable hydrogels. The hydrogels developed represent promising pro-angiogenic therapies, and can be easily adapted to control release of a variety of therapeutic molecules.
April 7, 2015 –
Department of Electrical and Computer Engineering
University of Rochester, Rochester, NY
Ph.D. Public Defense
Tuesday, April 7, 2015 at 2:00 PM
Hopeman Engineering Building, Room 335
Increasing Coverage and Improving Efficiency for RFID Systems and Wireless Sensor Networks
Presented by: Li Chen
Supervised by: Professor Wendi Heinzelman
Abstract: Radio-frequency identification (RFID), which uses radio-frequency electromagnetic fields to transfer data between an RFID reader and RFID tags in order to identify and track objects, has been widely deployed in recent years. RFID systems have the advantages of low cost, easy deployment and high design flexibility, and hence are used for access control, commercial tracking, toll collection and asset management. Compared to other identification methods such as bar codes and QR codes, RFID tags can be accessed without a line of sight, which increases the flexibility of ID tracking.
One of the key limitations for RFID technology is coverage. An RFID system with better coverage can access more tags in a larger area with fewer RFID readers, which leads to lower cost, less access delay and higher tag access efficiency. My research begins with an investigation of the coverage problem for passive RFID tags. Due to the limitations of the transmission power, the coverage is limited. I developed and implemented a range extension approach for passive RFID tags using devices called EDGE devices. With the help of EDGE devices, the coverage of a single RFID reader can be doubled. Also, multiple EDGE devices can work cooperatively to further extend the coverage area.
Another challenge in RFID system design is the MAC protocol. Due to some hardware limitations, most RFID systems are designed to use a contention based MAC protocol, which leads to high collisions, low fairness and low scalability. I proposed a token based RFID MAC protocol called Token-MAC to address these issues. Token-MAC can achieve a higher tag rate than contention based protocols. Also, Token-MAC can provide higher fairness performance, and it increases the scalability of the RFID system as well. I implemented the Token-MAC protocol in a programmable RFID tag and evaluated the performance of Token-MAC. I also compared the performance of Token-MAC with a TDMA approach and the standard RFID protocol called C1G2 in experiments and through simulations.
As passive RFID tags can be powered by an electromagnetic field, it is possible to use these devices to build a wake-up radio for Wireless Sensor Networks (WSNs). Passive wake-up radios can greatly increase the operational lifetime for a wireless sensor node by eliminating idle listening, when the node is awake but not transmitting or receiving data. However, due to the limited amount of energy harvested by an RFID tag, the limited wake-up range is a problem for passive wake-up radio sensor nodes. Most passive wake-up radio receivers can only work with a wake-up distance much shorter than the communication range. In this thesis, I present a passive wake-up radio design for Wireless Sensor Networks with extended wake-up range. This wake-up radio utilizes a high efficiency power harvesting receiver, a low power wake-up trigger circuit, and a wireless sensor node to build a passive wake-up sensor node called a REACH-Mote.
Furthermore, due the high efficiency power harvesting receiver and the com- pact RFID transmitter, it is possible to build a sensor node that operates using the energy obtained from the power harvester rather than from a battery and utilizes the harvested energy to transmit energy to nodes further away, waking up a second level of nodes. This potential network topology may lead to a new design in wireless sensor networks.
In summary, I have developed 1) an RFID range extension method using EDGE devices that improves the coverage of RFID systems; 2) Token-MAC, an RFID MAC protocol that improves the performance of the RFID system; 3) passive wake-up radio sensor nodes called REACH-Mote and REACH2-Mote designed for wireless sensor networks; and 4) a multi-hop passive radio wake-up sensor node. These designs improve the performance of RFID systems and wireless sensor networks, enhancing the network stability, throughput and lifetime and enabling new applications of RFID systems and wireless sensor networks.
April 8, 2015 –
University of Rochester
Department of Electrical and Computer Engineering
AME Audio for Visual Media
Guest Lecturer Series
Pop Cap Games, Seattle
Audio for Gaming
Wednesday, April 8th at 12:00PM – 1:00PM
Computer Studies Building, Room 209
Guy Whitmore is a composer specializing in video game music, notable for creating the soundtracks to Die Hard: Nakatomi Plaza, Russian Squares, Shivers, Shivers II: Harvest of Souls, Blood, Blood II: The Chosen, Shogo: Mobile Armor Division and No One Lives Forever. He is the co-founder of a music production company called Music Design Network, and a founding member of the Seattle Composers Alliance.
Guy Whitmore has specialized in creating "adaptive music" for video games, using techniques such as cross-fading, location-based music, and techniques to render music "on-the-fly" rather than using "pre-rendered" linear tracks. He is currently the Studio Audio Director for Pop Cap Games, an Electronic Arts label, overseeing new and classic franchises such as Bejeweled, Plants vs. Zombies, and Peggle.
April 9, 2015 –
Mentor Development Workshop
Please join us a special presentation by Cynthia N. Fuhrmann, PhD, Assistant Dean of Career and Professional Development at the Graduate School of Biomedical Sciences, and Assistant Professor of Biochemistry & Molecular Pharmacology, University of Massachusetts Medical School.
Scientists today face tremendous challenges-from keeping research funded to competing in a saturated job market. To address this reality, NIH recently mandated that all PI's report on the use of Individual Development Plans (IDP) by students and postdocs. Dr. Fuhrmann, co-author of the online tool "myIDP" hosted by AAAS/Science, will describe the benefits and challenges of creating an IDP and tools to assist in this process. She will end by discussing ways to incorporate IDPs and career development into graduate or postdoctoral training while maximizing research productivity, using the NIH BEST-funded UMass Medical School curriculum as one model.
When: Thursday, April 9th from 11:45 a.m. – 1:00 p.m.
Where: K-207 Auditorium (Room #2-6408)
Lunch is provided – Click here to RSVP
For graduate students and postdocs only- special session to follow Sponsored by The Clinical and Translational Science Institute and The Office of Faculty Development and Diversity “Using Individual Development Plans to enhance both research productivity and career development”.
April 9, 2015 –
The Center for Professional Development presents a special session for graduate students and postdocs with Cynthia N. Fuhrmann, PhD, Assistant Dean of Career and Professional Development at the Graduate School of Biomedical Sciences, and Assistant Professor of Biochemistry & Molecular Pharmacology, University of Massachusetts Medical School.
Dr. Fuhrmann is the co-author of the online tool “myIDP” hosted by AAAS/Science. This session will give graduate students and postdocs the opportunity to interact with Dr. Fuhrmann and informally discuss questions you have regarding your own individual development plans.
When: Thursday, April 9th from 2:00 – 4:00 p.m.
Where: Northeastern Conference Room (1-9535)
Click here to RSVP
Light refreshments will be served
The Center for Professional Development’s mission is the supplement every trainee’s scientific education with professional and career development opportunities most appropriate to each individual trainee’s interests and skills.
April 9, 2015 –
The Hajim School of Engineering and Applied Sciences
Together with the Society of Women Engineers
and the Gwen M. Greene Career and Internship Center
FROM ENGINEERING TO MANAGEMENT:
AN ALUMNAE PANEL
Reception to follow
Thursday, April 9
How do engineers enter the fields of “business” or “management”? Hear the stories of four women who leveraged their engineering backgrounds to become corporate leaders at Johnson & Johnson, Xerox, ADP, and Wegmans. Learn about career paths in engineering management, as well as fields you may not have considered (or even heard of), including operations, supply chain, process improvement, technical sales, consulting, and more. The panelists will also share valuable advice for budding technical leaders!
All class years and majors are encouraged to attend this special event! After the panel, mingle with the panelists at an informal dessert reception.
RSVP at http://goo.gl/forms/JeqGJDfD7n
or email email@example.com
April 10, 2015 –
The Graduate Student Society at the University of Rochester Medical Center is hosting a charity gala this Friday evening and we would like to extend a sincere invitation to all the graduate students on River Campus.This event will take place at the Casa Larga Vineyards & Winery. We are offering food, wine tasting, gift cards raffle, cash bar, live music and winery tours. The ticket price is $10 without wine tasting and $20 with wine tasting. Each ticket also includes 2 raffle tickets for winning gift cards from popular stores like Wegmans. All ticket sales go to the Dream Factory of Rochester, a charity organization that grants dreams to critically and chronically ill children from the age three through eighteen. Tickets are on sale at the Graduate Education and Postdoctoral Affairs (GEPA) Office at the University of Rochester Medical Center. The GEPA office is located next to the Atrium in the School of Medicine & Dentistry Building at the Medical Center, which is at the corner of Elmwood and Kendrick. Please visit our secretary Lauren Keppler at G-9556 once you arrive at the Medical Center. Thank you all very much and I hope to see you there!
April 13, 2015
April 13, 2015: Leadership Speaker: Robert Duffy "Composing a Career"
What: Young Leaders @ UR Bi-Annual Leadership Speaker event with Bob Duffy
April 18, 2015 –
GSA Laser Tag!
De-stress and celebrate the end of the semester with FREE laser tag! GSA is having three private games THIS Saturday, 4/18, at Laser Quest. Bring a friend and come any time between 7 p.m. for the first game and 8:20 p.m. for the start of the last game!
April 24, 2015 –
Final Future Faculty Workshop of 2014-15 registration is now open.
**PLEASE NOTE THE CHANGE OF LOCATION**
“Managing the Work/Life Juggle” with
Professor Jee will bring the insights she shares regularly in workshops for the American Academy of Pediatrics and throughout URMC, on successfully balancing multi-layered, complex and demanding, personal and professional lives. She will address questions that UR doctoral students and post-docs raised when polled on this topic: “How do I avoid worrying about work when I get home?” “How do you spend enough time with your children while still succeeding in science, with an 80+ hours a week schedule?” “How do I fit in exercise?”
This will be a fun and interactive workshop, with focus on both general questions of balance, and perspectives from different disciplines. Panelists from the Rochester faculty, who are themselves in the thick of the juggle, will join her in sharing their struggles and their strategies for staying personally happy and professionally productive throughout their academic careers.
A lunch buffet will be included.
April 24, 2015 –
“Managing the Work/Life Juggle.”
Friday, April 24th
LeChase Hall, Genrich-Rusling Room, #215
Associate Professor of Pediatrics Sandra Jee, M.D., M.P.H., will bring the insights she shares regularly in workshops for the American Academy of Pediatrics and throughout URMC, on successfully balancing multi-layered, complex and demanding, personal and professional lives. She will address questions that UR doctoral students and post-docs raised when polled on this topic: “How do I avoid worrying about work when I get home?” “How do you spend enough time with your children while still succeeding in science, with an 80+ hours a week schedule?” “How do I fit in exercise?”
“How do I maintain my relationship?”
Professor Jee will deliver a fun and interactive workshop, with focus on both general questions of balance, and perspectives from different disciplines. Panelists from the Rochester faculty, who are themselves in the thick of the juggle, will join her in sharing their struggles and their strategies for staying personally happy and professionally productive throughout their academic careers.
As always, lunch will be included, and to celebrate the culmination of a successful fifth Workshop season, we’re going to exchange our customary brown bag sandwich meal for a full-on luncheon buffet, arrayed with fresh salads, entrees and sweets.
The invitation to register for the session will follow in the coming weeks.