NYS Thruway I-90 to Exit 46, onto I-390N, then follow directions for "From the South" below.
I-390N to Exit 16, E. Henrietta Rd.. (NY Rt. 15A) and W. Henrietta Rd.. (NY Rt. 15) (This exit follows right after 390N has split into 590N going off to the right, and 390N continuing on to the left; be sure to stay to the left. Prior to this split there is an earlier exit on 390N for E. Henrietta Rd.. - do not take this!) At Exit 16, continue on the exit ramp straight across E. Henrietta Rd.. - keep to the right; the left lane merges back again onto 390N. Cross W. Henrietta Rd.. onto E. River Rd.. At second traffic light take right onto Kendrick Rd.. (LLE is on left, NSRL is on right as you approach this intersection). Go straight on Kenrick Rd.., which crosses over 390N and the barge canal. At end of Kendrick Rd.. (Strong Hospital is in front of you) bear left at traffic light onto Lattimore Rd.. At second traffic light bear left onto Elmwood Ave. Go under old railroad tressel that says "University of Rochester" and take first right onto Wilson Blvd. (if you cross the Genesee River, you have gone too far!). On Wilson Blvd. proceed to the Information Booth for token and parking directions.
NYS Thruway I-90 to Exit 47, onto I-490E. Take I-490E to I-390S. Take I-390S to Exit 17, Scottsville Rd.. (NY Rt. 383). Go left onto Scottsvill Rd.. then bear right at traffic light onto Elmwood Ave. Continue on Elmwood Ave. over Genesee River, then take first left at traffic light onto Wilson Blvd. On Wilson Blvd. proceed to the Information Booth for token and parking directions.
On exiting the airport, take a right onto Brooks Ave., and then almost immediately thereafter, take a right onto I-390S. Take I-390S to Exit 17 and follow corresponding directions for "From the West" above.