What Would You Give Me for this Red Paperclip?

The SPARK Entrepreneurs club is holding a 24-hour Red Paperclip Challenge for students at all levels of study from Friday, March 20 to Saturday, March 21. Event registration starts at 6:00 p.m. on Friday in the Rettner Hall atrium. The event will kick off with an introduction about the Challenge, ice-breakers, and optional brainstorming sessions. Over the next 24 hours, SPARK e-board members will take shifts operating the table in Rettner, where they will be offering free coffee and help for participants. The Rettner screen will display a live Twitter feed of the teams’ documented trade transactions. At 6:00 p.m. the following night, all participants will return and present their final item to three judges. Three winners will be selected and awarded cash prizes. The event will close with food, networking, and live DJing from WRUR. Watch the trailer and pre-register on Facebook.

2014 Newcomb Cleveland Prize Honors Discovery of the Brain’s Glymphatic System

Research that has transformed scientists’ understanding of the brain and neurodegenerative diseases like Alzheimer’s has been awarded the 2014 Newcomb Cleveland Prize of the American Association for the Advancement of Science (AAAS).

The Association’s oldest honor, the prize annually recognizes the author or authors of an outstanding paper published in the journal Science, and will be awarded this year for a study that appeared in the October 2013 edition of journal, entitled “Sleep Drives Metabolite Clearance from the Adult Brain.” The prize will be presented on Friday, February 13, at the AAAS Annual Meeting in San Jose, California.

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Norwest’s iCardiac Seeks to Be Game-Changer with New Cardiac Safety Test

Amy Or, Wall Street Journal, 17 December 2014

Norwest Venture Partners’ portfolio company iCardiac Technologies Inc. may have a way to help pharmaceutical companies detect which experimental drugs might flat line over cardiac concerns.

The Rochester, N.Y.-based company recently completed a study in collaboration with the U.S. Food and Drug Administration which demonstrated that cardiac toxicity in drugs can be detected much earlier in the development process than previously thought by medical professionals.

Read the complete article here.

Rochester Receives I-Corps Award to Advance Discoveries

The National Science Foundation today announced that the University of Rochester has been selected for an I-Corps site Award. This 3-year, $300,000 award will give Rochester the resources necessary to support further development of as many as 30 projects per year. Funds may be used to explore markets, conduct customer discovery inquiries, develop prototypes, or otherwise transition scientific discoveries into viable products and services. Any discovery made through NSF funding is eligible for consideration.

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The Smart Mouse with the Half-Human Brain

Dr. Goldman’s human glial mouse model has been written up in New Scientist.

The idea is not to mimic fiction, but to advance our understanding of human brain diseases by studying them in whole mouse brains rather than in dishes.

The altered mice still have mouse neurons – the “thinking” cells that make up around half of all their brain cells. But practically all the glial cells in their brains, the ones that support the neurons, are human.

“It’s still a mouse brain, not a human brain,” says Steve Goldman of the University of Rochester Medical Center in New York. “But all the non-neuronal cells are human.”

Read the entire article

Researchers Share Experiences at 2014 Rochester Drug Discovery Symposium

Four prominent Rochester researchers shared the state of their research and their experiences discovering and developing useful drugs. Mark Noble, Ph.D., (Biomedical Genetics), Paul Dunman, Ph.D. (Microbiology & Immunology), Harold Smith, Ph.D. (Biochemistry & Biophysics), and Richard Phipps, Ph.D. (Environmental Medicine) all spoke about some of the interesting projects they are working on and some of the struggles and successes they have encountered along the way.

Omar Bakht of UR Ventures opening the 2014 Rochester Drug Discovery Symposium.

Omar Bakht of UR Ventures opening the 2014 Rochester Drug Discovery Symposium.

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2014 Rochester Drug Discovery Symposium

Pharmadva Moves In To Lennox Tech Enterprise Center

High Tech Rochester’s Lennox Tech Enterprise Center, by virtue of its association with the University of Rochester, is a tax-free zone under the new START-UP NY economic development program.
Taking advantage of HTR’s designation, PharmAdva LLC (www.pharmadva.com), a startup healthcare technology company with roots at the University of Rochester, will locate at HTR. PharmAdva produces and markets an in-home medication-adherence system designed to help people manage multiple medications at home and avoid unnecessary hospitalization or nursing home admission.

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