Xerox Engineering Research Fellows
2018 Research Opportunities
Research Project #1: Hydrogel Culture Environments for Regenerative Medicine Applications
We can interrogate and take advantage of the critical interactions between cells and extracellular matrix (ECM) to create bioactive materials capable of controlling cell function and tissue evolution. To determine the requirements of the microenvironment, we utilize hydrogels easily modified with respect to mechanical integrity, adhesive peptides, ECM molecules, degradability, and incorporation of drugs, to direct cellular differentiation through a variety of mechanisms.
In particular, we are interested in utilizing hydrogel microenvironments to direct encapsulated mesenchymal stem cell (adult stem cell) function for applications in musculoskeletal tissue engineering. A thorough understanding of how material properties effect cell differentiation and tissue evolution is essential to tailor ‘instructive materials’ to direct cell function.
Research Project #2: Targeted Polymer Therapeutics to Overcome Drug Delivery Barriers
Conventional small molecule drugs and large macromolecular drugs have significant and distinctly different delivery barriers. For example, small molecule drugs, such as the chemotherapeutic doxorubicin, is highly hydrophobic, thus administration requires toxic cosolvents to aid blood solubility. Macromolecular drugs, on the other hand, suffer from enzymatic degradation and inactivation, difficulty in targeting to the appropriate cells and transversing the cell membrane, and often become degraded intracellularly once endocytosed. We are investigating polymer-drug complexes or polymer-drug conjugates to overcome these barriers and modulate drug delivery.
Solid state thin film lithium metal batteries represent the greatest success in energy storage miniaturization. They provide high energy and power densities (when neglecting packaging), remarkable rate performance, long lifetimes, and safe, flexible integration given their solid state construction. The undergraduate research assistant will synthesize and characterize new thin film electrodes for incorporation into these thin film batteries. Physical vapor deposition techniques will be used to synthesize the materials. Preliminary characterization will be achieved through the fabrication and cycling of full battery cells. The student should have a strong background in chemistry and preferably materials science.