Materials Science

Professor Amoako Abstract

Amoako pic

Professor Kagya Amoako
University of New Haven
Department of Biomedical Engineering
Nitric Oxide Releasing Polymer-based Systems for Anti-clotting Anti-bacterial Applications



Nitric oxide (NO), awarded molecule of the year in 1992, is synthesized by brain cells (neurons), vascular cells, macrophages, and the liver for many physiological functions including inhibiting platelet aggregation and acting as an antimicrobial agent. Several systems for the delivery of NO have been studied in order to develop nonthrombogenic and bactericidal surfaces/materials for medical and non-medical applications. This presentation focuses on some of the remaining challenges limiting the translation of NO releasing materials from the primarily pre-clinical research stage into clinical use. Specifically, the conjugation of NO to polymers, controlled release of NO from polymers, bactericidal yet safe to healthy cells levels of NO studies, and application of the NO releasing material to model catheters will be highlighted. Ultimately, an optimized NO releasing polymer platform will find use in applications such as NO releasing wound dressings to accelerate wound healing in people living with foot ulcers (63.3 million worldwide), leg ulcers (6.4 million in the US), bed sores (33% of all critical care incidences in the US), and burn injuries, NO releasing coatings for blood-contacting devices to better control clot formation and implant site infection, cancer research, and also for controlling surgical site infection.