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MEDIA CONTACT: Peter Iglinski peter.iglinski@rochester.edu
585.273.4726
July 28, 2011
The Goal is to Help Other Researchers Develop New Compounds
Scientists don't always get the opportunity to test the molecules of their choice. As Assistant Professor of Chemistry Daniel Weix points out, "Half of all options are rejected because they're too expensive or take too long to make." Weix hopes to make it easier for researchers to test new chemical compounds by changing the way some molecules are formed.
The National Institutes of Health (NIH) is making it possible for Weix to carry out his research, thanks to a $1.45 million grant over the next five years.
Weix, who has spent three years doing initial work on catalytic bond formation, focuses on organic halides as the starting materials because they are stable, affordable, and readily available. "Given enough time and money, we can make almost anything, but time and money are not infinite," said Weix. "This chemistry should change that by allowing scientists to make and test more molecules."
One industry that could benefit from Weix's research is pharmaceuticals. "Time and cost are real barriers to discovering new compounds," said Weix. "If it can't be made and tested, then no one knows if it can be used as a drug."
Weix works in the field of cross-coupling, which makes use of transition metals to bring molecules together to form new carbon-carbon bonds. Cross-coupling typically involves the combination of an electrophile—a substance that attracts electrons—with a nucleophile—a substance that donates electrons. But Weix says nucleophiles are "troublesome" because they are generally not commercially available and are air and moisture-sensitive. So Weix and his group are replacing the nucleophile with another electrophile. The challenge, he says, is creating a catalyst that will selectively form a bond between the two unlike electrophiles.
The University of Rochester (www.rochester.edu) is one of the nation's leading private universities. Located in Rochester, N.Y., the University gives students exceptional opportunities for interdisciplinary study and close collaboration with faculty through its unique cluster-based curriculum. Its College of Arts, Sciences, and Engineering is complemented by the Eastman School of Music, Simon School of Business, Warner School of Education, Laboratory for Laser Energetics, Schools of Medicine and Nursing, and the Memorial Art Gallery.
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