{"id":250792,"date":"2017-06-22T12:08:41","date_gmt":"2017-06-22T16:08:41","guid":{"rendered":"http:\/\/www.rochester.edu\/newscenter\/?p=250792"},"modified":"2017-07-11T07:36:14","modified_gmt":"2017-07-11T11:36:14","slug":"wasp-venom-holds-clues-genes-get-new-jobs-250792","status":"publish","type":"post","link":"https:\/\/www.rochester.edu\/newscenter\/wasp-venom-holds-clues-genes-get-new-jobs-250792\/","title":{"rendered":"Wasp venom holds clues on how genes get new jobs"},"content":{"rendered":"<p>Amid the incredible diversity of living things on our planet, there is a common theme. Organisms need to acquire new genes, or change the functions of existing genes, in order to adapt and survive.<\/p>\n<p>How does that happen?<\/p>\n<p>A common view is that genes duplicate, with one of the copies picking up a new function while the other copy continues to function as before.<\/p>\n<p>However, by studying tiny parasitic Jewel Wasps and their rapidly changing venom repertoires, the<strong><a href=\"http:\/\/www.werrenlab.org\/\"> Werren Lab at the University of Rochester<\/a><\/strong> has uncovered a different process that may be widespread in other species as well.<\/p>\n<div class=\"embed-container\"><iframe loading=\"lazy\" src=\"https:\/\/www.youtube.com\/embed\/pTa2ikfQyW8\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/div>\n<p class=\"video-caption\"><strong>WATCH<\/strong>: \u201cIt is almost as if they are now moonlighting. They\u2019ve got a day job, and then take on a night job as well. Over time, if the night job works out, they may give up the day job and evolve as a venom specialist. However, in other cases we have found that they stop moonlighting as venom genes but appear to retain their day job.\u201d<\/p>\n<hr \/>\n<p>The process involves co-opting single copy genes to take on new functions. In some cases, these genes appear to continue their previous function as well, in other parts of the wasp\u2019s anatomy besides the venom gland. The findings are published in <em>Current Biology<\/em>.<\/p>\n<ul>\n<li><a href=\"http:\/\/www.cell.com\/current-biology\/fulltext\/S0960-9822(17)30568-7\"><strong>Read the original study<\/strong><\/a><\/li>\n<\/ul>\n<p>\u201cIt is almost as if they are now moonlighting,\u201d says <strong><a href=\"http:\/\/www.sas.rochester.edu\/bio\/people\/faculty\/werren_john\/\">John (Jack) Werren, the Nathaniel and Helen Wisch Professor in Biology<\/a><\/strong>. \u201cThey\u2019ve got a day job, and then take on a night job as well. Over time, if the night job works out, they may give up the day job and evolve as a venom specialist. However, in other cases we have found that they stop moonlighting as venom genes but appear to retain their day job.\u201d<\/p>\n<p>How is a gene co-opted? And what determines which job (or combination of jobs) it performs? In the case of Jewel Wasps, the process called gene regulation is key. As the researchers explain, the rapid turnover in venom genes is accomplished mostly by changes in regulatory regions adjacent to the genes. These regulatory regions control how the genes are expressed\u2014that is, whether the genes are turned \u201con\u201d or \u201coff\u201d in different tissues. When a gene is turned on, it provides instructions for manufacturing proteins. When it\u2019s turned off, it provides no such instructions.<\/p>\n<p>&#8220;Co-option of single copy genes can be a more rapid mechanism for adapting to a new environment because it does not require the gene to be duplicated first,&#8221; notes Ellen Martinson, a co-lead author and postdoctoral research associate in the Werren Lab.<\/p>\n<p>\u201cIn essence, these wasps are recycling their genes for new functions,&#8221; says co-lead Mrinalini, a former postdoc in the Werren Lab who has since joined the National University of Singapore, where she studies snake venoms.<\/p>\n<figure id=\"attachment_252722\" aria-describedby=\"caption-attachment-252722\" style=\"width: 800px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-252722 size-full\" src=\"https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2017\/06\/jack-werren-wasp-venom.jpg\" alt=\"Jack Werren in his lab, sitting in front of a computer image of a wasp\" width=\"800\" height=\"534\" srcset=\"https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2017\/06\/jack-werren-wasp-venom.jpg 800w, https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2017\/06\/jack-werren-wasp-venom-630x421.jpg 630w, https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2017\/06\/jack-werren-wasp-venom-768x513.jpg 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><figcaption id=\"caption-attachment-252722\" class=\"wp-caption-text\">Jack Werren, the Nathaniel and Helen Wisch Professor in Biology, leads the Werren Lab, whose research focus is evolutionary and functional genetics. (University photo \/ J. Adam Fenster)<\/figcaption><\/figure>\n<figure id=\"attachment_252712\" aria-describedby=\"caption-attachment-252712\" style=\"width: 800px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-252712 size-full\" src=\"https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2017\/06\/ellen-martinson-wasp-venom.jpg\" alt=\"Ellen Martinson smiles in her lab\" width=\"800\" height=\"534\" srcset=\"https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2017\/06\/ellen-martinson-wasp-venom.jpg 800w, https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2017\/06\/ellen-martinson-wasp-venom-630x421.jpg 630w, https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2017\/06\/ellen-martinson-wasp-venom-768x513.jpg 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><figcaption id=\"caption-attachment-252712\" class=\"wp-caption-text\">Ellen Martinson, postdoctoral research associate in the Werren Lab and co-lead on this latest study. Her work involves looking at 120 million years of the evolution of parasitoid wasp venom. (University photo \/ J. Adam Fenster)<\/figcaption><\/figure>\n<figure id=\"attachment_252732\" aria-describedby=\"caption-attachment-252732\" style=\"width: 800px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-252732 size-full\" src=\"https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2017\/06\/mrinalini-wasp-venom.jpg\" alt=\"woman holding a snake\" width=\"800\" height=\"530\" srcset=\"https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2017\/06\/mrinalini-wasp-venom.jpg 800w, https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2017\/06\/mrinalini-wasp-venom-630x417.jpg 630w, https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2017\/06\/mrinalini-wasp-venom-768x509.jpg 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><figcaption id=\"caption-attachment-252732\" class=\"wp-caption-text\">Mrinalini, co-lead on this study and former member of the Werren Lab group, now studies snake venom at National University of Singapore. (University photo \/ courtesy Mrinalini)<\/figcaption><\/figure>\n<p>The group\u2014which also includes two other researchers at the University of Rochester, Yogeshwar Kelkar and Ching-Ho Chang\u2014studied four closely related species of Jewel Wasps. The wasps lay their eggs on the pupae of other insects, after first injecting the pupae with venoms that manipulate the metabolism of the host in ways that make the environment more conducive to their developing young.<\/p>\n<p>Using transcriptome and proteome sequencing, the researchers found that more than half of the venom components in the parasitic wasps resulted from single copy genes that had been co-opted without being duplicated. The composition of the venoms can change quickly, allowing the wasps to adapt to different hosts. For example, even closely related species can differ by up to 40 percent of their venom repertoire.<\/p>\n<figure id=\"attachment_252692\" aria-describedby=\"caption-attachment-252692\" style=\"width: 800px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-252692 size-full\" src=\"https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2017\/06\/wasp-venom1.jpg\" alt=\"tiny wasp sitting on a person's fingertip\" width=\"800\" height=\"534\" srcset=\"https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2017\/06\/wasp-venom1.jpg 800w, https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2017\/06\/wasp-venom1-630x421.jpg 630w, https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2017\/06\/wasp-venom1-768x513.jpg 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><figcaption id=\"caption-attachment-252692\" class=\"wp-caption-text\">Parasitoid venoms, like those from the Jewel Wasp, could be developed into new pharmaceuticals and drugs. &#8220;It&#8217;s a vast potential resource for new drug discovery,&#8221; says professor Jack Werren. (University photo \/ J. Adam Fenster)<\/figcaption><\/figure>\n<p>The group proposes that co-option of single copy genes for new function is not just restricted to parasitoid venoms. Co-option may be common in nature, particularly when organisms are evolving rapidly to changing environments.<\/p>\n<p>With regards to parasitoid venoms, there may be an added benefit, says Werren. &#8220;The great diversity of parasitoid venoms and abundance of these species (estimates run as high as 600,000 parasitoid species on earth), combined with the fact that parasitoid venoms have evolved to manipulate metabolic processes, suggests that they are potentially an immense untapped cornucopia for drug discovery.&#8221;<\/p>\n<p>Professor Werren can be contacted at <strong><a href=\"mailto:jack.werren@rochester.edu\"><span id=\"ctl00_MainContentArea_GVFacultyResults_ctl03_lblEmail\">jack.werren@rochester.edu<\/span><\/a><\/strong>, Ellen Martinson at <strong><a href=\"mailto:e.martinson@rochester.edu\"><span id=\"ctl00_MainContentArea_GVFacultyResults_ctl03_lblEmail\">e.martinson@rochester.edu<\/span><\/a><\/strong> and Mrinalini can be reached at <a href=\"mailto:dbsmrin@nus.edu.sg\"><strong>dbsmrin@nus.edu.sg<\/strong><\/a>.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>University researchers studying the venom of parasitic wasps believe a relatively understudied mechanism for creating new gene functions may be widespread in other species as well.<\/p>\n","protected":false},"author":286,"featured_media":252632,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[116],"tags":[18722,18792,18572,16072],"class_list":["post-250792","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sci-tech","tag-department-of-biology","tag-genetics","tag-research-finding","tag-school-of-arts-and-sciences"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Wasp venom 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