{"id":369142,"date":"2019-04-14T12:23:13","date_gmt":"2019-04-14T16:23:13","guid":{"rendered":"http:\/\/www.rochester.edu\/newscenter\/?p=369142"},"modified":"2019-07-19T09:51:07","modified_gmt":"2019-07-19T13:51:07","slug":"novel-drug-therapies-danielle-benoit-369142","status":"publish","type":"post","link":"https:\/\/www.rochester.edu\/newscenter\/novel-drug-therapies-danielle-benoit-369142\/","title":{"rendered":"Professor\u2019s \u2018tinkering\u2019 ways lead to novel drug therapies"},"content":{"rendered":"

Women of Invention<\/a> is a Newscenter series of profiles of women at the University who hold international patents. More than half of the University’s patent applications\u00a0from 2011 to 2015 include women.<\/em><\/h4>\n

As she was being recruited by the University of Rochester, Danielle Benoit<\/a> had an opportunity to meet with Edward Puzas<\/a>, the Donald and Mary Clark Professor in Orthopaedics and an expert in bone remodeling.<\/p>\n

\u201cJust to talk about what he was doing, what I was doing, and what we might do together,\u201d recalls Benoit, an associate professor of biomedical engineering.<\/p>\n

Puzas told her about his research into the \u201ccrosstalk\u201d that occurs between the cells that continually remodel our bones. He had discovered that the osteoclasts<\/em> in charge of breaking down depleted bone tissue leave behind \u201cmolecular signatures\u201d\u2014so the osteoblasts<\/em> charged with rebuilding the bone will recognize where they are needed.<\/p>\n

\u201cIs that at all interesting?\u201d Puzas asked her. \u201cCould that be useful for something?\u201d<\/p>\n

\u201cYes\u2014and yes,\u201d was Benoit\u2019s reply. That conversation was one of the reasons why Benoit ended up accepting a faculty position in the University\u2019s Department of Biomedical Engineering.<\/a><\/p>\n

The number of women among the department\u2019s faculty members was another.<\/p>\n

\u201cIt wasn\u2019t just women who were junior faculty members, but women who were senior and very well established, and who had thriving research programs,\u201d Benoit says. \u201cTo me, that suggested that Rochester was going to support that kind of career development.\u201d<\/p>\n

\"Danielle
Danielle Benoit at work in her lab with doctoral students Maureen Newman, left, and Yuchen Wang. Benoit has been honored by the University for her mentorship of her students, who she encourages to \u201ckeep exploring, keep learning.\u201d (University of Rochester photo \/ J. Adam Fenster)<\/figcaption><\/figure>\n

The close proximity of the department to the University\u2019s medical center, just across Elmwood Avenue, was also \u201ccritical,\u201d she says. It offered Benoit easier access to basic science researchers like Puzas who could help her advance her work in tissue regeneration, and also the targeted delivery of therapeutic drugs, which she began as a postdoc.<\/p>\n

For example, the fact that osteoclasts leave behind molecular signatures \u201cis a fantastic way to target bone drug delivery to exactly where it\u2019s needed,\u201d Benoit says.<\/p>\n

Here\u2019s how: One of those molecular signatures is a protein called tartrate-resistant acid phosphatase, or TRAP. Working with Puzas, Benoit\u2019s lab began to design a nanoparticle-sized polymer drug-delivery device that includes a peptide that binds to TRAP. In theory, the package could be loaded with therapeutic drugs to enhance the bone rebuilding process\u2014in the case of a fracture\u2014or to boost the performance of deficient osteoblasts\u2014in the case of osteoporosis, or chronic bone thinning. It might even be used to target leukemia stem cells deep in the marrow of bone.<\/p>\n

\u201cBy getting those drugs directly to the osteoblasts, we would have greater impact,\u201d Benoit says. \u201cAnd because we\u2019re delivering the drugs to just that particular cell type, we would reduce the possibility of \u2018off-target\u2019 side effects in other parts of the body.<\/p>\n

\u201cIt took a number of years, but that\u2019s what we\u2019ve done.\u201d<\/p>\n

The result was US Patent #9,949,950: \u201cCompositions and Methods for Controlled Localized Delivery of Bone Forming Therapeutic Agents,\u201d one of nine approved or pending patents Benoit has co-authored.<\/p>\n

\u201cIt wasn\u2019t just women who were junior faculty members, but women who were senior and very well established, and who had thriving research programs.\u201d<\/div>\n

Another of her patents, with Hyun Koo at the University of Pennsylvania, is for a nanoparticle carrier that binds to tooth enamel<\/a>. It releases a therapeutic drug to reduce plaque and prevent tooth decay at exactly the right time, triggered by acidic levels that occur in the presence of glucose, starch, and other food products that cause tooth decay.<\/p>\n

\u2018Always tinkering\u2019 as a kid<\/strong><\/h3>\n

Benoit, who grew up in Maine, says she was \u201calways tinkering\u201d as a kid, making race tracks for matchbox cars, for example. She remembers tagging along with her father at work for a couple of days. He was trained as a forester, but worked essentially as a civil engineer, designing remote logging roads for his company. \u201cI remember all the survey equipment and other gadgets he had. I thought that was really cool,\u201d Benoit says.<\/p>\n

She would spend hours exploring the woods next to her home.<\/p>\n

\u201cI loved every science class that that I came across,\u201d she adds. \u201cEven in middle school, I remember going into earth science and thinking \u2018this is so cool.\u2019 \u201d<\/p>\n

She was the first student to graduate in bioengineering from the University of Maine. She completed her PhD in chemical engineering at the University of Colorado in Boulder, then did her postdoctoral research at the University of Washington in Seattle. She developed a delivery system for nucleic acid drugs, \u201cwhich are really challenging to deliver,\u201d for cancer therapy.<\/p>\n

She says she\u2019s thankful that she was schooled in the importance of disclosing technologies developed in an academic lab, and in securing patents for them.<\/p>\n

\u201cThat\u2019s critical, if we want to see what we have developed become a product that\u2019s going to help people, especially a drug delivery system or tissue engineering product. It\u2019s going to take an investment in safety and efficacy studies, and clinical trials, and so much development that is beyond the scope of what we can do in our labs,\u201d Benoit says. \u201cA company is not going to be interested unless the technology is protected. It\u2019s not going to be worth it to them if another company is going to do it, too.\u201d<\/p>\n

She delivers the message to the students in her lab, including more than 80 undergraduates she has mentored since joining the University in 2010.<\/p>\n

\u201cThese students are challenged with true research projects, are provided excellent training in key skills, and are guided by a hierarchy of mentors and role models that includes graduate students, post-doctoral fellows, and Professor Benoit herself,\u201d says Diane Dalecki<\/a>, the Kevin J. Parker Distinguished Professor in Biomedical Engineering and department chair. \u201cIt is impressive how often undergraduate students are included as co-authors on papers from Professor Benoit\u2019s laboratory.\u201d<\/p>\n

\u201cKeep exploring, keep learning,\u201d is Benoit\u2019s advice for young would-be inventors and researchers.<\/p>\n

That\u2019s the path she followed, from the woods of Maine to cutting-edge research and inventions at the University of Rochester.<\/p>\n","protected":false},"excerpt":{"rendered":"

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