{"id":485392,"date":"2021-07-15T15:50:01","date_gmt":"2021-07-15T19:50:01","guid":{"rendered":"https:\/\/www.rochester.edu\/newscenter\/?p=485392"},"modified":"2025-11-19T07:59:33","modified_gmt":"2025-11-19T12:59:33","slug":"virtual-patient-sophie-prepares-doctors-for-end-of-life-conversations-485392","status":"publish","type":"post","link":"https:\/\/www.rochester.edu\/newscenter\/virtual-patient-sophie-prepares-doctors-for-end-of-life-conversations-485392\/","title":{"rendered":"A new way to prepare doctors for difficult conversations"},"content":{"rendered":"<h2 style=\"width: 85%; font-weight: bold; line-height: 135%; margin-bottom: 0.5em;\">University of Rochester researchers have developed SOPHIE, a virtual \u2018patient\u2019 that trains doctors in explaining end-of-life options.<\/h2>\n<p>As many as 68 percent of late-stage cancer patients leave their doctor\u2019s offices either <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/nejmoa1204410\">underestimating the severity of their disease<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27415765\/\">overestimating their life expectancy<\/a>\u2014or both. These misunderstandings can hinder the ability of patients and their families to make realistic decisions about whether to continue aggressive treatments or instead turn to palliative care.<\/p>\n<p>To address the problem, <a href=\"https:\/\/rochester.edu\">University of Rochester<\/a> computer scientists, palliative care specialists, and practicing oncologists are perfecting SOPHIE (Standardized Online Patient for Healthcare Interaction Education)\u2014an online virtual \u201cpatient\u201d that helps physicians practice how to communicate effectively with late-stage cancer patients about their disease.<\/p>\n<p>Effective communication in this context often means demonstrating empathy and understanding of the complex emotions that patients are experiencing.<\/p>\n<p>\u201cDuring difficult conversations about facing the potential of one\u2019s own death, patients are frightened and don\u2019t know how to ask the right questions, and clinicians may oversimplify, omit, or sugar-coat information, or feel too pressed for time to address patients\u2019 emotions,\u201d says <a href=\"https:\/\/www.cs.rochester.edu\/people\/faculty\/hoque_m.ehsan\/index.html\">Ehsan Hoque<\/a>, an associate professor of <a href=\"https:\/\/www.cs.rochester.edu\">computer science<\/a> at Rochester\u2019s Hajim School of Engineering and Applied Sciences. The COVID-19 pandemic has made effective communication even more difficult by causing increasing reliance on virtual rather than in-person interactions between patients and physicians, adds Hoque.<\/p>\n<p>Hoque is a pioneer in the area of research that shows it is possible for people to learn and improve their social and interpersonal skills by interacting with automated systems. For example, he helped develop LISSA (Live Interactive Social Skills Assistant)\u2014a tool that\u2019s been used effectively by people on the autism spectrum\u2014in collaboration with professor of computer science Len Schubert.<\/p>\n<div class=\"embed-container\">\n<iframe loading=\"lazy\" width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/1QVXZo14pLw\" title=\"YouTube video player\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe>\n<\/div>\n<h3><strong>Practicing end-of-life conversations<\/strong><\/h3>\n<p>SOPHIE is possible because of a body of nearly 400 conversations that were recorded between late-stage cancer patients and their oncologists, and initially analyzed by palliative care expert <a href=\"http:\/\/www.ronaldepstein.com\">Ronald Epstein<\/a> and his collaborators at the <a href=\"https:\/\/www.urmc.rochester.edu\">University of Rochester Medical Center<\/a>. Epstein\u2019s <a href=\"https:\/\/www.urmc.rochester.edu\/family-medicine\/research\/communication-disparities.aspx\">Center for Communication and Disparities Research<\/a> focuses on how to improve communication between clinicians, patients, and their loved ones.<\/p>\n<p>A <a href=\"https:\/\/arxiv.org\/abs\/2009.11247\">paper<\/a> in <em>IEEE Transactions on Affective Computing<\/em> describes how lead author Mohammad Rafayet Ali, a postdoctoral researcher, and PhD student Taylan Sen, both members of Hoque\u2019s <a href=\"https:\/\/roc-hci.com\">Rochester Human-Computer Interaction (ROC HCI) Lab<\/a>, created algorithms that could be applied to the transcripts of these conversations, so the researchers could develop metrics to assess a physician\u2019s ability to communicate clearly with patients.<\/p>\n<p>The metrics focus specifically on the extent that physicians engage in lecturing\u2014delivering a lot of information without giving the patient a chance to ask questions or to respond\u2014or, on the plus side, how well they employ \u201csentiment trajectory\u201d\u2014using positive words and phrases in ways associated with increased patient understanding.<\/p>\n<div class=\"pullquote\">\u201cThe online format can provide training at a fraction of the cost and be made available to physicians worldwide.\u201d<\/div>\n<p>The researchers used a physician communication training protocol, developed by Epstein and his collaborators, to script SOPHIE\u2019s practice sessions, and enlisted nine practicing oncologists at the University to try the system.<\/p>\n<p>\u201cWe received a lot of feedback from the doctors on how natural the conversation was, the kinds of questions SOPHIE should ask, and the concerns a typical patient might raise,\u201d Ali says.<\/p>\n<p>\u201cIn our prior research, physicians practiced with trained actors to learn how to bring up difficult issues, such as prognosis and end-of-life care,\u201d Epstein says. \u201cBut actors can be costly. The online format can provide training at a fraction of the cost and be made available to physicians worldwide. And Ehsan Hoque\u2019s group is on the cutting edge.\u201d<\/p>\n<p>The researchers are now fine-tuning SOPHIE. \u201cOur hope is that once we have demonstrated its efficacy through a randomized controlled experiment, first-year students at the Medical Center can practice with it,\u201d Hoque says.<\/p>\n<p>The demo has been designed to be available through a computer browser, allowing physicians from anywhere around the world to practice their skills live and receive feedback on their speaking rate, turn-taking, type of questions asked and sentiment trajectory.<\/p>\n<p>SOPHIE could help raise awareness of palliative care as an option. \u201cIn many parts of the world, there is no palliative care. People only focus on how to treat the cancer,\u201d Ali says.<\/p>\n<hr style=\"width: 50%;\" \/>\n<h3><strong>SOPHIE says<\/strong><\/h3>\n<figure id=\"attachment_485472\" aria-describedby=\"caption-attachment-485472\" style=\"width: 1000px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-485472 size-full\" src=\"https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2021\/07\/inline-SOPHIE-training-graphics.jpg\" alt=\"Illustration of information provided by SOPHIE, including speaking rate, number of questions asked, number of open-ended questions asked, turn taking, and sentiment trajectory.\" width=\"1000\" height=\"743\" srcset=\"https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2021\/07\/inline-SOPHIE-training-graphics.jpg 1000w, https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2021\/07\/inline-SOPHIE-training-graphics-630x468.jpg 630w, https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2021\/07\/inline-SOPHIE-training-graphics-768x571.jpg 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><figcaption id=\"caption-attachment-485472\" class=\"wp-caption-text\">(University of Rochester illustration \/ Michael Osadciw)<\/figcaption><\/figure>\n<p>A sample conversation with SOPHIE works something like this:<\/p>\n<p>SOPHIE appears as a real-life\u2014albeit, AI-derived\u2014human face on the user&#8217;s screen.<\/p>\n<p>She introduces herself and mentions that she has lung cancer. Then SOPHIE raises the topic of her sleep pattern at night and asks if she needs to change her pain medication, allowing the physician to assess her perception. She states that her current pain medication, Lortab, is not working anymore.<\/p>\n<p>As the doctor responds, SOPHIE begins collecting data so that she can provide the doctor with an end-of-conversation assessment resembling the image above.<\/p>\n<p>SOPHIE then turns attention to her test results, giving the physician a chance to engage SOPHIE in more difficult topics, before asking more specifically about her prognosis.<\/p>\n<p>SOPHIE next asks about other options and expresses some additional fears and concerns, providing the physician with opportunities to respond empathically.<\/p>\n<p>Finally, she follows up by discussing whether chemotherapy remains an option, whether she should focus on comfort care, what the side effects of chemotherapy are, and how to break the news to her family, allowing the physician to summarize information and suggest a strategy.<\/p>\n<hr style=\"width: 50%;\" \/>\n<h3><strong>Close proximity fosters collaboration<\/strong><\/h3>\n<p>The SOPHIE project is a shining example of the research collaborations that are possible as a result of the close proximity of the University of Rochester Medical Center to the rest of the University. The River Campus, for example, is just a five-minute walk away.<\/p>\n<p>The project had its origins seven years ago when Hoque, who had just joined the University, spoke to a digital media studies class on the River Campus. \u201cAn undergraduate student in the class was employed by Ron Epstein\u2019s lab,\u201d Hoque says. \u201cShe talked to Ron and suggested we should talk. We hit it off right away.\u201d<\/p>\n<p>Hoque and his lab members were impressed by Epstein\u2019s work on improving communication between terminally ill patients and their physicians. They were especially excited by the research possibilities presented by the patient-physician transcripts that Epstein and his collaborators had begun analyzing.<\/p>\n<p>\u201cThey did all the hard work in collecting high-stakes conversations of cancer patients,\u201d Hoque says. \u201cWe were fortunate to be at the right place at the right time to leverage the data and their expertise.<\/p>\n<p>\u201cThis wasn\u2019t part of Rafayet\u2019s and Tay\u2019s thesis trajectories at all, and we didn\u2019t have any funding to do the work. But we knew that we needed to find a way to do this exciting work.\u201d<\/p>\n<p>Other collaborators coauthors of the paper include Thomas Carroll, associate professor of medicine; Lenhart Schubert, professor of computer science; Benjamin Kane (advised by Schubert); and Shagun Bose, an undergraduate researcher in the Hoque Lab.<\/p>\n<hr \/>\n<h3><strong>Read more<\/strong><\/h3>\n<div class=\"large-up-3\">\n<div class=\"column\" style=\"padding-left: 0px;\"><a href=\"https:\/\/www.rochester.edu\/newscenter\/ehsan-hoque-named-an-emerging-leader-by-national-academy-of-medicine-432082\/\"><img decoding=\"async\" style=\"margin-bottom: 10px;\" src=\"https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2020\/05\/fea-Ehsan-Hoque.jpg\" alt=\"Ehsan Hoque in a suit stands in front of Wegmans Hall on an overcast day.\" \/><strong>Ehsan Hoque named an \u2018emerging leader\u2019 by National Academy of Medicine<\/strong><\/a><br \/>\n<span style=\"font-size: .9em;\">The director of Rochester\u2019s Human-Computer Interaction Lab is one of ten leaders selected to work with the organization on \u201csparking transformative change to improve health care for all.\u201d<\/span><\/div>\n<div class=\"column\" style=\"padding-left: 0px;\"><a href=\"https:\/\/www.rochester.edu\/newscenter\/intersections-app-combines-virtual-reality-personalized-psychotherapy-cognitive-behavioral-therapy-296922\/\"><img decoding=\"async\" style=\"margin-bottom: 10px;\" src=\"https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2018\/02\/fea-VR-psychotherapy-app.jpg\" alt=\"still image from a virtual reality app features a female clinical psychologist in an office setting.\" \/><strong>Virtual reality app offers personalized psychotherapy<\/strong><\/a><br \/>\n<span style=\"font-size: .9em;\">A multidisciplinary team of University doctors, engineers, and musicians worked together to create an immersive, customized experience that brings cognitive-behavioral therapy to a patient\u2019s smartphone.<\/span><\/div>\n<div class=\"column\" style=\"padding-left: 0px;\"><a href=\"https:\/\/www.rochester.edu\/newscenter\/machine-learning-advances-human-computer-interaction\/\"><img decoding=\"async\" style=\"margin-bottom: 10px;\" src=\"https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2017\/03\/robotHoward.jpg\" alt=\"man with robot holding a coffee cup in front of him\" \/><strong>Machine learning advances human-computer interaction<\/strong><\/a><br \/>\n<span style=\"font-size: .9em;\">Researchers at Rochester are developing computer programs incorporating machine learning to teach robots and software to understand natural language and body language, make predictions from social media, and model human cognition.<\/span><\/div>\n<\/div>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>University of Rochester researchers have developed SOPHIE, a virtual \u2018patient\u2019 that trains doctors in explaining end-of-life 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