{"id":515582,"date":"2022-03-16T12:29:09","date_gmt":"2022-03-16T16:29:09","guid":{"rendered":"https:\/\/www.rochester.edu\/newscenter\/?p=515582"},"modified":"2022-04-13T10:36:13","modified_gmt":"2022-04-13T14:36:13","slug":"aging-alzheimers-junk-dna-515582","status":"publish","type":"post","link":"https:\/\/www.rochester.edu\/newscenter\/aging-alzheimers-junk-dna-515582\/","title":{"rendered":"Connecting the dots between aging, Alzheimer\u2019s, and \u2018junk DNA\u2019"},"content":{"rendered":"<h2 style=\"width: 85%; font-weight: bold; line-height: 135%; margin-bottom: 0.5em;\">A new grant will enable biologists at Rochester, Brown, and New York University to explore potential targets of treatments and therapeutics for neurodegenerative diseases.<\/h2>\n<p>The human genome is littered with selfish genetic elements, also known as \u201cjunk DNA\u201d\u2014parasitic strands of genetic material that replicate and move within their host genomes. Scientists have produced mounting evidence that these selfish genetic elements cause harmful consequences, including health problems associated with aging.<\/p>\n<p>With a new $16 million, five-year grant from the National Institutes of Health, researchers from the <a href=\"https:\/\/www.rochester.edu\/\">University of Rochester<\/a>, Brown University, and New York University will collaborate to further investigate how types of selfish genetic elements called retrotransposons affect age-related pathologies. Specifically, they will concentrate on the role retrotransposons play in Alzheimer\u2019s disease and neurodegeneration.<\/p>\n<p>The team\u2014led by principal investigator John Sedivy at Brown and including <a href=\"https:\/\/www.sas.rochester.edu\/bio\/people\/faculty\/gorbunova_vera\/\">Vera Gorbunova<\/a>, the Doris Johns Cherry professor of <a href=\"http:\/\/www.sas.rochester.edu\/bio\/\">biology<\/a> at Rochester and codirector of the <a href=\"https:\/\/www.urmc.rochester.edu\/university-of-rochester-aging-institute\/research\/roar-center.aspx\">Rochester Aging Research Center<\/a>, and\u00a0<a href=\"http:\/\/www.sas.rochester.edu\/bio\/people\/faculty\/seluanov_andrei\/\">Andrei Seluanov<\/a>, professor of biology at Rochester\u2014will also search for targets to inform therapeutic strategies to treat those conditions.<\/p>\n<p>\u201cThis project will combine investigators with expertise in retrotransposons, aging, and neuroscience to understand the role of transposons is Alzheimer\u2019s disease and test whether targeting transposons alleviates Alzheimer\u2019s symptoms,\u201d Gorbunova says.<\/p>\n<h3><strong>Previous research: retrotransposons promote aging<\/strong><\/h3>\n<p>With support from a <a href=\"https:\/\/www.brown.edu\/news\/2016-09-06\/retrotransposition\">prior NIH grant<\/a>, Gorbunova, Seluanov and the rest of their team have been researching the mechanisms of aging with special attention to the potentially harmful effects of retrotransposons. Evidence from this team and other scientists has implicated retrotransposons in promoting aging.<\/p>\n<p>Gorbunova and Seluanov have focused their research on a class of selfish genetic elements called LINE1 retrotransposons, which are the most prevalent retrotransposons found in humans; LINE1 retrotransposons occupy close to 20 percent of both human and mice genomes. Researchers have long suspected that LINE1s contribute to cancer and genomic instability because they are repressed in young tissues but become more active during aging, triggering inflammation in cells.<\/p>\n<p>In 2019, the researchers published studies in the journals <a href=\"https:\/\/www.nature.com\/articles\/s41586-018-0784-9\"><em>Nature<\/em><\/a> and <a href=\"https:\/\/www.rochester.edu\/newscenter\/selfish-genetic-elements-amplify-inflammation-and-age-related-diseases-367632\/\"><em>Cell Metabolism<\/em><\/a> showing that LINE1s promote age-associated inflammation in cells. In 2021, they published a <a href=\"https:\/\/www.nature.com\/articles\/s41586-021-03542-y\">review article in <em>Nature<\/em><\/a> discussing the latest research on retrotransposons.<\/p>\n<h3><strong>Targeting LINE1 retrotransposons<\/strong><\/h3>\n<p>With the new NIH funding, the research team will join colleagues from the <a href=\"https:\/\/www.salk.edu\/\">Salk Institute for Biological Studies<\/a> to study how retrotransposons contribute to neurodegeneration and chronic, age-related diseases such as Alzheimer\u2019s disease.<\/p>\n<p>Their research will include an investigation of the mechanisms that lead aging cells and other defense systems to fail in preventing retrotransposons from spreading and how the cells of the central nervous system respond to retrotransposons. The central nervous system appears to be a hotbed of retrotransposon activity, as retrotransposons have relatively high levels of expression in this region.<\/p>\n<p>Gorbunova and Seluanov will focus on testing the hypothesis that silencing LINE1s via genetic or pharmacological approaches will alleviate age-related pathologies.<\/p>\n<p>\u201cWe will employ different strategies of targeting the negative effects of LINE1s, including silencing their expression, inhibiting retrotransposition, or downregulating LINE1-induced inflammation,\u201d Seluanov says. \u201cWe will then test if these treatments alleviate Alzheimer\u2019s symptoms in mouse models.\u201d<\/p>\n<p>The team will also examine and define therapeutic targets specific to the central nervous system and explore possible strategies for therapeutic interventions and future pharmaceutical research in treating diseases such as Alzheimer\u2019s.<\/p>\n<p>\u201cWe hope that our research will lead to a novel approach for treating Alzheimer\u2019s disease by targeting LINE1s,\u201d Gorbunova says.<\/p>\n<hr \/>\n<h3><strong>Read more<\/strong><\/h3>\n<div class=\"large-up-3\">\n<div class=\"column\" style=\"padding-left: 0px;\"><a href=\" https:\/\/www.rochester.edu\/newscenter\/is-junk-dna-a-key-to-killing-cancer-cells-495992\/ \"><img decoding=\"async\" style=\"margin-bottom: 10px;\" src=\"https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2021\/10\/fea-junk-dna-cancer-research.jpg\" alt=\"trunk filled with rusty tools and other junk.\" \/><strong>Is \u2018junk DNA\u2019 a key to killing cancer cells?<br \/>\n<\/strong><\/a><span style=\"font-size: .9em;\">Rochester biologists show how a selfish genetic element called retrotransposons that can cause tumors may also trigger the death of cancer cells.<\/span><\/div>\n<div class=\"column\" style=\"padding-left: 0px;\"><a href=\"https:\/\/www.rochester.edu\/newscenter\/selfish-genetic-elements-amplify-inflammation-and-age-related-diseases-367632\/\"><img decoding=\"async\" style=\"margin-bottom: 10px;\" src=\"https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2019\/03\/fea-aging-hands.jpg\" alt=\"aging person's hands folded over a cane.\" \/><strong>\u2018Selfish\u2019 genetics amplify inflammation, age-related diseases<\/strong><\/a><br \/>\n<span style=\"font-size: .9em;\">Research from Rochester biologists shows that a class of genomic parasites may cause more harm than previously thought, triggering inflammation that causes age-related diseases.<\/span><\/div>\n<div class=\"column\" style=\"padding-left: 0px;\"><a href=\"https:\/\/www.rochester.edu\/newscenter\/study-suggests-how-high-blood-pressure-might-contribute-to-alzheimers-360432\/\"><img decoding=\"async\" style=\"margin-bottom: 10px;\" src=\"https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2019\/01\/fea-high-blood-pressure-alzheimers.jpg\" alt=\"illustration of fluid moving through an artery.\" \/><strong>Study suggests how high blood pressure might contribute to Alzheimer\u2019s<\/strong><\/a><br \/>\n<span style=\"font-size: .9em;\">New Rochester research may help explain the connection between high blood pressure and Alzheimer\u2019s disease, and it\u2019s all to do with how the brain pumps away waste.<\/span><\/div>\n<\/div>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Biologists Vera Gorbunova and Andrei Seluanov join colleagues at Brown and NYU in the quest to find potential targets of treatments and therapeutics for neurodegenerative diseases.<\/p>\n","protected":false},"author":912,"featured_media":515702,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[116],"tags":[10916,18722,9186,16072,10906],"class_list":["post-515582","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sci-tech","tag-andrei-seluanov","tag-department-of-biology","tag-research-funding","tag-school-of-arts-and-sciences","tag-vera-gorbunova"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Connecting the dots between aging, Alzheimer\u2019s, and \u2018junk DNA\u2019<\/title>\n<meta name=\"description\" content=\"An NIH grant will enable biologists at Rochester, Brown, and NYU to explore relationship between &#039;junk DNA&#039; 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