{"id":561592,"date":"2023-06-20T11:20:36","date_gmt":"2023-06-20T15:20:36","guid":{"rendered":"https:\/\/www.rochester.edu\/newscenter\/?p=561592"},"modified":"2023-06-27T09:31:41","modified_gmt":"2023-06-27T13:31:41","slug":"lipid-droplets-fertility-egg-development-561592","status":"publish","type":"post","link":"https:\/\/www.rochester.edu\/newscenter\/lipid-droplets-fertility-egg-development-561592\/","title":{"rendered":"The hidden role of lipid droplets in fertility and beyond"},"content":{"rendered":"

Once thought of merely as fat storages, lipid droplets are now believed to play important roles in human health and fertility.<\/h2>\n

Within our cells are structures called lipid droplets that serve as storage units for energy in the form of lipids or fats. Because fat is an important energy source for cells and organisms, scientists had long assumed that lipid droplets had a straightforward role during egg production, as energy providers for the developing embryo.<\/p>\n

In the past few years, however, scientists have found that lipid droplets play additional roles. Researchers at the University of Rochester<\/a> and the University of Iowa<\/a> recently discovered that lipid droplets play a vital role during the development of eggs in fruit flies. In a paper published<\/a> in the journal Development<\/em>, the researchers report that lipid droplets provide a signal that triggers cellular changes necessary for the growth of the egg\u2014and could affect fertility in myriad organisms.<\/p>\n

\u201cWe suspect this function is widespread and may also contribute to fertility in humans,\u201d says Michael Welte<\/a>, a professor in the Department of Biology<\/a>, who led the Rochester group.<\/p>\n

The researchers found that during egg production, a signal is generated by an enzyme on the surface of the lipid droplets. The enzyme releases a specific type of lipid called arachidonic acid. The arachidonic acid is then converted into signaling molecules called prostaglandins. Prostaglandins stimulate the cell to rearrange its internal structure and prepare for the next stage of egg development.<\/p>\n

When the enzyme on the lipid droplets is absent, prostaglandin production is affected, leading to defects in cell structure and impaired egg maturation.<\/p>\n

Previous research has shown that prostaglandins have various other significant roles in human health, including regulating fever, pain, and inflammation.<\/p>\n

\u201cMany of us frequently use medication to suppress prostaglandin production, such as aspirin and ibuprofen,\u201d Welte says. In certain cells of the human immune system, there is a connection between lipid droplets and prostaglandin production.<\/p>\n

But Welte\u2019s research shows that the connection between lipid droplets and prostaglandin production is not limited to immune cells. The research suggests lipid droplets may be instrumental for prostaglandin production in other tissues as well, making them key players in multiple biological processes.<\/p>\n

\u201cLipid droplets support a critical step in producing an egg,\u201d he says, \u201cand we now speculate that lipid droplets may influence even more processes in animal development by modulating prostaglandin signals.\u201d<\/p>\n

\n

Read more<\/strong><\/h3>\n
\n
\n

\"cheeseLipid droplets play crucial roles beyond fat storage<\/strong><\/a><\/p>\n

Long thought of merely as formless blobs of fat, lipids are now proving crucial for understanding how embryos survive and how obesity affects the body.<\/span><\/p>\n<\/div>\n

\n

\"Fruit\u2018Supergene\u2019 wreaks havoc in a genome<\/strong><\/a><\/p>\n

Rochester biologists have for the first time used population genomics to study a selfish \u2018supergene\u2019 known as Segregation Distorter (SD) that skews genetic inheritance.<\/span><\/p>\n<\/div>\n

\n

\"youngGene regulation may hold clue to longer life<\/strong><\/a><\/p>\n

Rochester biologists who study the genetics of lifespan suggest new targets to combat aging and age-related diseases.<\/span><\/p>\n<\/div>\n<\/div>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Research on fruit flies led by Michael Welte, a professor of biology, finds that lipid droplets play a role in cellular changes necessary for the growth of the egg\u2014and could affect fertility in myriad organisms.<\/p>\n","protected":false},"author":912,"featured_media":561952,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[116],"tags":[18722,29502,17052,18572,16072],"class_list":["post-561592","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sci-tech","tag-department-of-biology","tag-featured-post-side","tag-michael-welte","tag-research-finding","tag-school-of-arts-and-sciences"],"acf":[],"yoast_head":"\nThe hidden role of lipid droplets in fertility and beyond<\/title>\n<meta name=\"description\" content=\"Once thought of merely as fat storages, lipid droplets are now believed to play important roles in human health and 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