{"id":589512,"date":"2024-01-09T12:49:35","date_gmt":"2024-01-09T17:49:35","guid":{"rendered":"https:\/\/www.rochester.edu\/newscenter\/?p=589512"},"modified":"2025-11-19T07:58:46","modified_gmt":"2025-11-19T12:58:46","slug":"tissue-on-chip-drug-development-tool-trace-bmps-589512","status":"publish","type":"post","link":"https:\/\/www.rochester.edu\/newscenter\/tissue-on-chip-drug-development-tool-trace-bmps-589512\/","title":{"rendered":"New NIH-funded center could soon reduce the need for pharmaceutical trials on animals"},"content":{"rendered":"

Rochester is one of four NIH-sponsored centers that aims to produce tissue-on-chip devices as FDA-qualified drug development tools.<\/h2>\n

The University of Rochester<\/a> will house a new national center focused on using tissue-on-chip technology to develop drugs more rapidly and reduce the need for animal trials. The National Institutes of Health awarded<\/a> a $7.5 million grant to establish the Translational Center for Barrier Microphysiological Systems (TraCe-bMPS) at Rochester in partnership with Duke University.<\/p>\n

The center aims to develop five Food and Drug Administration\u2013qualified drug development tools related to study barrier functions in disease\u2014interfaces in tissue that are critical for the progression of infection, cancer, and many autoimmune disorders. Over the five-year grant, the researchers will create drug development tools specifically related to central nervous system disorders, fibrosis, musculoskeletal autoimmune disease, sepsis, and osteomyelitis.<\/p>\n

The TraCe-bMPS scientists will create the drug development tools using microphysiological systems\u2014small chips with ultrathin membranes of human cells. They will be built using the modular, mass-producible \u00b5SiM chips pioneered by center director James McGrath<\/a>, the William R. Kenan Jr. Professor of\u00a0Biomedical Engineering<\/a><\/p>\n

\u201c<\/span>Drug discovery is moving into an era where fewer animals are used to test for safety and efficacy.\u201d<\/div>\n

McGrath says that testing drugs on \u00b5SiM chips can lead to fewer animal trials. And because researchers will be studying the drugs\u2019 effects on human cells, they may also help overcome some of the critical differences between testing on humans and animals.<\/p>\n

\u201cDrug discovery is moving into an era where fewer animals are used to test for safety and efficacy,\u201d says McGrath. \u201cInstead, more screening will be done on tissue chips that pattern human cells in a way that mimics human tissue and disease. Our chips are designed to provide the higher throughput and more reliable indications that pharmaceutical companies need to get their drugs approved for clinical trials and use by patients.\u201d<\/p>\n

\"Top-down
\u2018CLINICAL TRIALS ON CHIP\u2019:<\/strong> The chips produced by TraCe-bMPS will feature photonic biosensors crafted by Benjamin Miller, a Dean\u2019s Professor of Dermatology at Rochester with joint appointments in biomedical engineering, biochemistry and biophysics, optics, and materials science. (University of Rochester photo \/ Benjamin Miller Lab).<\/figcaption><\/figure>\n

Hani Awad<\/a>, the Donald and Mary Clark Distinguished Professor in Orthopaedics<\/a> and a professor of biomedical engineering, will serve as the associate director for development. He says Congress passing the FDA Modernization Act 2.0<\/a> in 2022 made the center possible and that the team is excited to help shape the future of drug development.<\/p>\n

\u201cThe timing could not be more perfect,\u201d says Awad. \u201cAs a biomedical engineer and scientist, I find the elegant fusion of engineering and biology inherent in the design and validation of these tissue chips as disease models and drug-testing platforms to be one of the most rewarding pursuits in my professional career. I can\u2019t wait to see what this team will be developing over the next five years, and beyond.\u201d<\/p>\n

The chips will feature photonic biosensors crafted by Benjamin Miller<\/a>, a Dean\u2019s Professor of Dermatology<\/a> at Rochester with joint appointments in\u00a0biomedical engineering<\/a>,\u00a0biochemistry and biophysics<\/a>,\u00a0optics<\/a>, and\u00a0materials science<\/a>. Miller, the center\u2019s associate director for resources, says the center is the culmination of years of research and collaboration.<\/p>\n

\u201cGetting our devices qualified by the FDA as drug development tools will mean that we\u2019re a step closer to doing \u2018clinical trials on chip\u2019 with fully human models, increasing the likelihood of a drug candidate being successful when it actually gets to human clinical trials,\u201d says Miller. \u201cThis is also a great opportunity to build an interdisciplinary training environment for our students and expand a collaboration with my colleagues that has been very productive.\u201d<\/p>\n

\"Two
CHIPPING IN:<\/strong> Biomedical engineering PhD students Danial Ahmad (L) and Molly McCloskey assemble fixtures used to guide components and membrane chips to create the modular \u00b5SiM tissue chip platform, featuring an ultrathin nanomembrane. (University of Rochester photo \/ J. Adam Fenster)<\/figcaption><\/figure>\n

Joan Adamo<\/a>, director of the Office of Regulatory Support<\/a> at the University of Rochester Medical Center\u2019s Clinical and Translational Science Institute<\/a>, will serve as associate director for qualification and will prepare all submissions to the FDA for qualification. Adamo says she sees the ambitious program having far-reaching implications.<\/p>\n

\u201cThis unique program involves close collaboration with the FDA through a series of qualification steps\u2014a critical aspect to addressing unmet needs,\u201d says Adamo. \u201cI am looking forward to working closely with the agency and our collaborators on this regulatory science project. We will achieve qualification of these vital drug development tools, which will accelerate research conducted at URMC and be shared with other academic health centers and industry programs.\u201d<\/p>\n

George Truskey, the R. Eugene and Susie E. Goodson Distinguished Professor of Biomedical Engineering at Duke University, will serve as associate director and direct collaborative activities at Duke University. The TRaCE-bMPS is also supported by a deep network of co-investigators at Rochester, Duke, and Rochester Institute of Technology, a distinguished advisory board, expert consultants, and key industry partners. The NIH grant is expected to fund TRaCE-bMPS through fiscal year 2028 (FY28).<\/p>\n

The research funding is provided by the National Institute on Aging of the National Institutes of Health under Award Number U2CAG088071. The content in this article is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

Rochester is one of four NIH-sponsored centers that aims to produce tissue-on-chip devices as FDA-qualified drug development tools.<\/p>\n","protected":false},"author":1242,"featured_media":589522,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[42472,116],"tags":[28572,18742,18632,18652,19182,37312,9186],"class_list":["post-589512","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-medicine","category-sci-tech","tag-benjamin-miller","tag-department-of-biomedical-engineering","tag-hajim-school-of-engineering-and-applied-sciences","tag-institute-of-optics","tag-james-mcgrath","tag-materials-science-program","tag-research-funding"],"acf":[],"yoast_head":"\nNew NIH-funded center could soon reduce the need for pharmaceutical trials on animals<\/title>\n<meta name=\"description\" content=\"TraCe-bMPS is one of four NIH-sponsored 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