{"id":718912,"date":"2026-09-08T14:31:51","date_gmt":"2026-09-08T18:31:51","guid":{"rendered":"https:\/\/www.rochester.edu\/newscenter\/?p=718912"},"modified":"2026-09-08T14:31:51","modified_gmt":"2026-09-08T18:31:51","slug":"protein-cgas-sting-pathway-inflammation-aging-718912","status":"publish","type":"post","link":"https:\/\/www.rochester.edu\/newscenter\/protein-cgas-sting-pathway-inflammation-aging-718912\/","title":{"rendered":"Removing an inflammation-linked protein makes aging worse"},"content":{"rendered":"<h2 style=\"font-weight: 400;\"><strong>URochester researchers have found that cGAS, a protein known for triggering inflammation, also plays a protective role.<\/strong><\/h2>\n","protected":false},"excerpt":{"rendered":"<p>URochester researchers have found that cGAS, a protein known for triggering inflammation, also plays a protective role.<\/p>\n","protected":false},"author":912,"featured_media":718992,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[42472,116],"tags":[10916,18722,18572,43102,16072,10906],"class_list":["post-718912","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-medicine","category-sci-tech","tag-andrei-seluanov","tag-department-of-biology","tag-research-finding","tag-research-impact-advances","tag-school-of-arts-and-sciences","tag-vera-gorbunova"],"acf":{"external":"","hide_featured_image":false,"related":"show_related","style":[674682,565032,622962],"content_modules":[{"acf_fc_layout":"text","anchor":"","css_class":"pt-10","title":"","content":"<h3><strong>Key findings:<\/strong><\/h3>\r\n<ul>\r\n \t<li>Removing the protein cGAS increased inflammation and frailty and shortened lifespan in mice\u2014the opposite of what researchers expected.<\/li>\r\n \t<li>cGAS has two seemingly opposing roles: It can trigger inflammation but also helps protect cells from it.<\/li>\r\n \t<li>The protein helps keep LINE1s, genetic elements that can contribute to age-related inflammation, switched off.<\/li>\r\n \t<li>The findings could help scientists develop more precise therapies for age-related inflammation.<\/li>\r\n<\/ul>","background_color":"#f4f4f4","width":"width-medium"},{"acf_fc_layout":"text","anchor":"","css_class":"","title":"","content":"Researchers at the <a href=\"http:\/\/www.rochester.edu\/\">University of Rochester<\/a> thought that shutting down a protein linked to inflammation might help slow aging. Instead, they found the opposite: Without the protein, mice became frailer, experienced more inflammation, and had shorter lifespans.\r\n\r\nThe unexpected result reveals that the protein, called cGAS, has two seemingly opposing roles. It can trigger inflammation when it detects DNA in the wrong place inside a cell. But researchers discovered it also helps prevent another source of the chronic inflammation associated with aging and age-related diseases.\r\n\r\nThe findings, <a href=\"https:\/\/www.nature.com\/articles\/s43587-026-01217-9\">published in <em>Nature Aging<\/em><\/a>, could have implications for developing treatments and therapies designed to target age-related inflammation.\r\n\r\n\u201cWe thought that getting rid of cGAS would be beneficial because of its role in inflammation, but instead we found that it made animals age faster,\u201d says <a href=\"https:\/\/www.sas.rochester.edu\/bio\/people\/faculty\/gorbunova_vera\/\">Vera Gorbunova<\/a>, the Doris Johns Cherry Professor in the\u00a0<a href=\"https:\/\/www.sas.rochester.edu\/bio\/index.html\">Department of Biology<\/a> and codirector of the\u00a0<a href=\"https:\/\/www.urmc.rochester.edu\/university-of-rochester-aging-institute\/research\/roar-center\">Rochester Aging Research (RoAR) Center<\/a>\u00a0and the\u00a0<a href=\"https:\/\/shockcenter.urlongevity.org\/\">Upstate NY Comparative Biology of Aging Nathan Shock Center<\/a>.\r\n<h3><strong>cGAS: A protein with two jobs<\/strong><\/h3>\r\nResearchers have long known that cGAS plays a role in inflammation. When the protein detects DNA in the cytoplasm\u2014the fluid-filled area outside a cell\u2019s nucleus\u2014it can activate an inflammatory protein called STING. Together, cGAS and STING form part of a cellular defense system known as the cGAS-STING pathway.\r\n\r\nBecause chronic activation of this pathway has been linked to aging and inflammation, researchers have been exploring whether blocking cGAS-STING could help reduce age-related chronic inflammation and preserve health as people grow older.\r\n\r\nBut when Gorbunova and her team removed cGAS from mouse models, they discovered another side of the protein.\r\n\r\nInside the cell\u2019s nucleus, cGAS helps maintain chromatin, the tightly organized structure that packages the cell\u2019s DNA. By keeping certain stretches of DNA tightly packed and inaccessible, chromatin helps suppress genetic elements called LINE1s.\r\n\r\nWithout cGAS, the researchers found, those normally suppressed elements become more active. That can lead to more LINE1-derived DNA entering the cytoplasm, where the cell can mistake it for a sign of danger and trigger inflammation.\r\n\r\nIn other words, cGAS has two seemingly opposing jobs. Outside the nucleus, it can act as an alarm system that detects misplaced DNA and activates inflammation. Inside the nucleus, cGAS helps prevent some of that potentially inflammatory DNA from being produced in the first place.\r\n<h3><strong>What is inflammation\u2014and what causes it?<\/strong><\/h3>\r\nInflammation is the body\u2019s natural immune response to injury or infection. In a young, healthy body, inflammation is an important short-term defense mechanism. But when inflammation persists, it can damage cells and tissues.\r\n\r\nAs people age, inflammation becomes more persistent and is associated with many diseases that become more common with age, including cancer, cardiovascular disease, and neurodegenerative disorders.\r\n\r\n\u201cReducing harmful, persistent inflammation may potentially reduce some of the cellular damage that contributes to disease and loss of function as we age,\u201d says <a href=\"https:\/\/www.sas.rochester.edu\/bio\/people\/faculty\/seluanov_andrei\/\">Andrei Seluanov<\/a>, a Dean\u2019s Professor of Biology at URochester and a coauthor of the study.\r\n\r\nOne source of inflammation lies within our own DNA.\r\n\r\nMuch of human DNA consists of genetic sequences that do little more than propagate themselves in their hosts. Among them are transposable elements called LINE1s, which can copy themselves and insert those copies elsewhere in the genome.\r\n\r\nCells have several ways of keeping transposable elements switched off. But <a href=\"https:\/\/www.rochester.edu\/newscenter\/selfish-genetic-elements-amplify-inflammation-and-age-related-diseases-367632\/\">previous research from Gorbunova\u2019s lab<\/a> has shown that LINE1s become more active with aging and can contribute to chronic inflammation.\r\n\r\nWhen LINE1s become active, they can produce DNA that escapes into the cytoplasm. There, the cell can mistake the DNA for an invading threat\u2014much as it would a virus\u2014and launch an inflammatory response.\r\n\r\nThe new findings show that cGAS, despite its own role in triggering inflammation, also helps keep this process in check.\r\n<h3><strong>Rethinking therapies for aging<\/strong><\/h3>\r\nThe findings present a challenge for scientists investigating ways to target cGAS to combat age-related inflammation. Eliminating or blocking cGAS might shut down one source of inflammation. But doing so could also remove one of the cell\u2019s defenses against another.\r\n\r\n\u201cRather than simply turning off the protein, future therapies may need to preserve its protective role in the nucleus while blocking its inflammatory activity elsewhere in cells,\u201d Gorbunova says.","background_color":"#ffffff","width":"width-medium"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Removing an inflammation-linked protein makes aging worse<\/title>\n<meta name=\"description\" content=\"URochester researchers have found that cGAS, a protein known for triggering inflammation, also plays a protective role.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.rochester.edu\/newscenter\/protein-cgas-sting-pathway-inflammation-aging-718912\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Removing an inflammation-linked protein makes aging worse\" \/>\n<meta property=\"og:description\" content=\"URochester researchers have found that cGAS, a protein known for triggering inflammation, also plays a protective role.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.rochester.edu\/newscenter\/protein-cgas-sting-pathway-inflammation-aging-718912\/\" \/>\n<meta property=\"og:site_name\" content=\"News Center\" \/>\n<meta property=\"article:published_time\" content=\"2026-09-08T18:31:51+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.rochester.edu\/newscenter\/wp-content\/uploads\/2026\/09\/fea-protein-cgas-sting-pathway-inflammation-aging-GettyImages-836255128-2-1200x630.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"630\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Lindsey Valich\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Lindsey Valich\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.rochester.edu\\\/newscenter\\\/protein-cgas-sting-pathway-inflammation-aging-718912\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.rochester.edu\\\/newscenter\\\/protein-cgas-sting-pathway-inflammation-aging-718912\\\/\"},\"author\":{\"name\":\"Lindsey Valich\",\"@id\":\"https:\\\/\\\/www.rochester.edu\\\/newscenter\\\/#\\\/schema\\\/person\\\/fcd7d29a5b8e855924bf73b764dcd827\"},\"headline\":\"Removing an inflammation-linked protein makes aging worse\",\"datePublished\":\"2026-09-08T18:31:51+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.rochester.edu\\\/newscenter\\\/protein-cgas-sting-pathway-inflammation-aging-718912\\\/\"},\"wordCount\":24,\"image\":{\"@id\":\"https:\\\/\\\/www.rochester.edu\\\/newscenter\\\/protein-cgas-sting-pathway-inflammation-aging-718912\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.rochester.edu\\\/newscenter\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/fea-protein-cgas-sting-pathway-inflammation-aging-GettyImages-836255128-2.jpg\",\"keywords\":[\"Andrei Seluanov\",\"Department of Biology\",\"research finding\",\"Research Impact Advances\",\"School of Arts and Sciences\",\"Vera Gorbunova\"],\"articleSection\":[\"Health &amp; 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