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Tag: Steve Goldman

Research to explore new therapies for Huntington’s disease

Research to explore new therapies for Huntington’s disease

October 12, 2016

A new grant anticipated to total more than $10.5 million over next five years will help Medical Center scientists develop a stem cell-based therapy that swaps sick brain cells for healthy ones.

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Swapping sick for healthy brain cells slows Huntington’s disease

Swapping sick for healthy brain cells slows Huntington’s disease

June 7, 2016

Medical Center researchers have successfully reduced the symptoms and slowed the progression of Huntington’s disease by replacing sick mouse glia cells with healthy human cells. The findings could ultimately point to a new method to treat the disease.

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Mice injected with human brain cells get smarter, scientists say

Mice injected with human brain cells get smarter, scientists say

December 9, 2014

“It’s still a mouse brain, not a human brain,” says Steve Goldman of the University of Rochester Medical Center in New York. “But all the non-neuronal cells are human.”

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Human foetus cells injected into baby mice to create ‘supermouse’

Human foetus cells injected into baby mice to create ‘supermouse’

December 4, 2014

Researchers at the University of Rochester Medical said it was like ‘ramping up the power’ of the mouse brain, because human cells are so much more advanced. They found that mice with the human brain cells had memories that were four times better than their siblings who did not have the injections.

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Half the cells in this mouse’s brain are human

Half the cells in this mouse’s brain are human

December 3, 2014

A new study explores the consequences of creating mice that have mousy neurons but human glial cells—cells that support nerve cells and strengthen connections between them.

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New tool allows researchers to target rare brain disease

New tool allows researchers to target rare brain disease

November 17, 2014

Progressive multifocal leukoencephalopathy is a rare brain disease found in patients with compromised immune systems. Until now, it has been almost impossible to track the disease or test treatments. But a new model developed at the Medical Center allows researchers to study the disease in mouse brains that contain both animal neurons and human glia cells.

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Research seeks to break new ground in understanding of schizophrenia

Research seeks to break new ground in understanding of schizophrenia

October 2, 2014

More than $6 million in funding from the National Institute of Mental Health is supporting new research led by Rochester’s Center for Translational Neuromedicine that could fundamentally alter the way we comprehend and, perhaps ultimately, treat schizophrenia.

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Brain Cells Lost to Huntington’s Disease Regenerated

Brain Cells Lost to Huntington’s Disease Regenerated

June 6, 2013

Scientists used a modified virus to infect target cells in the brains of affected mice, and trigger the sustained over-expression of proteins which, in turn, activated the neighboring neural stem cells to produce neurons.

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Genetic Signature of a Brain Cancer ID’d

Genetic Signature of a Brain Cancer ID’d

June 3, 2013

Using human tissue samples representing the three principal stages of the cancer, the researchers were able to identify and isolate the cancer-inducing stem cells.

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Knocking on the Door of Stem Cell Therapy

Knocking on the Door of Stem Cell Therapy

October 25, 2012 | 0 Comments

After decades of research in regenerative medicine, Medical Center scientists contend we are now on the threshold of human application of stem cell therapies for a class of neurological diseases known as myelin disorders – a list that includes conditions such as multiple sclerosis and cerebral palsy.

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