2015 News Archive
August 2, 2016
Biomedical Engineering Professor Mark Buckley received a grant from the American Orthopaedic Foot & Ankle Society (AOFAS) for his research project entitled, "In Vitro Assessment of the Role of Mechanical Strain in the Pathogenesis and Reversal of Insertional Achilles Tendinopathy." Insertional Achilles tendinopathy (IAT) is a common and painful disorder that responds poorly to conservative (i.e., nonoperative) care. Improved outcomes for IAT patients require interventions that target the fundamental causes of the disease. Thus, this study seeks to elucidate 1) how mechanical deformations occurring in the Achilles tendon insertion can lead to IAT pathogenesis (using an in vitro model); and 2) whether the IAT-associated changes can be reversed in vitro by specific mechanical loading regimens. The findings of this study will motivate effective, targeted non-surgical therapies for IAT.
July 28, 2016
Stephen McAleavey, associate professor of biomedical engineering, has received a $408,368 R21 grant from the National Institutes of Health for his project, "Quantification of Shear Wave Strain Dependence in Breast Tissues.” Many women presently undergo breast biopsy due to lesions detected with x-ray and ultrasound imaging. The great majority of these biopsies are negative, resulting in needless expense and worry. The goal of this project is to improve the power of ultrasound imaging to predict if a breast lesion is benign or malignant, by using a novel, high-resolution technique to non-invasively map the non-linear mechanical properties of breast tissue. These properties are determined by the microstructure of the tissue and show marked differences between benign and malignant tissues. Stephen’s co-investigators on this interdisciplinary project are Marvin Doyley, associate professor of electrical and computer engineering; Linda M. Schiffhauer, associate professor of pathology and laboratory medicine, and Avice O’Connell, professor of imaging sciences.
July 1, 2016
Even before Biomedical Engineering became a department, Diane Dalecki wrote the curriculum for what was then a fledgling interdepartmental program for undergraduates.
May 20, 2016
Congratulations to Marvin Doyley who will receive two University Research Awards this year! University Research Awards, previously known as Provost Multidisciplinary Awards, provide seed money on a competitive basis for innovative research projects that are likely to attract external support when sufficiently developed. See below for project descriptions:
May 5, 2016
Congratulations to graduate student Jonathan Langdon of the McAleavey Lab who received the prestigious Outstanding Dissertation Award for Engineering this year. This honor attests to Jonathan’s exceptional work in the field of biomedical ultrasound and comes with a monetary award of $1,000. His thesis was titled, “Development of Single Track Location Shear Wave Viscoelasticity Imaging for Real-Time Characterization of Biological Tissues.”
May 5, 2016
April 19, 2016
March 8, 2016
BME Professor Stephen McAleavey recently received a 9th percentile score for his R21 grant entitled, "Quantification of Shear Wave Strain Dependence in Breast Tissues.” Many women presently undergo breast biopsy due to lesions detected with x-ray and ultrasound imaging. The great majority of these biopsies are negative, resulting in needless expense and worry. The goal of this project is to improve the power of ultrasound imaging to predict if a breast lesion is benign or malignant. This will be achieved by a novel, high resolution technique to non-invasively map the non-linear mechanical properties of breast tissue. These properties are determined by the microstructure of the tissue and show marked differences between benign and malignant tissues.
December 1, 2015
Rohit Nayak, a Ph.D. candidate supervised by Prof. Marvin Doyley, presented a poster titled “Visualizing principal strains of the carotid artery using plane wave imaging” at the University of Rochester Center for AIDS Research (CFAR) World AIDS Day Symposium on December 1st. Rohit was awarded “Best Graduate Student Poster” in the Clinical/Translational/Public Health Category for his work! Co-authored by Rifat Ahmed and Marvin Doyley (Electrical & Computer Engineering), Prashant Verma (Physics & Astronomy) Nancy Carson and Vikram Dogra (Imaging Sciences), Meera Singh and Sanjay Maggirwar (Microbiology & Immunology), and Giovanni Schifitto (Neurology), the poster presented the promising results from an ongoing NIH-supported HIV/vascular aging project. Congratulations to Rohit and his co-authors on a job well done!
September 3, 2015
The patent titled “Chimeric Fibronectin Matrix Mimetics and Uses Thereof” (US 9,072,706) has recently been assigned to the University of Rochester with inventors Denise Hocking, Ph.D. (Pharmacology and Physiology, BME, RCBU) and Daniel Roy, Ph.D. (BME PhD 2012 alumnus). The patent relates to a series of recombinant fibronectin peptide mimetics developed to promote wound repair. The technology falls under a new and exciting class of therapies known as wound biologics. The primary commercial application for this technology is to promote healing of hard-to-heal or chronic wounds, including diabetic, venous, and pressure ulcers, which impose a significant health care burden worldwide. Encouraging results from recent studies indicate that topical application of these fibronectin peptide mimetics to full-thickness excisional wounds in diabetic mice accelerates wound closure and promotes granulation tissue deposition, remodeling, and re-vascularization. Denise Hocking is an Associate Professor of Pharmacolog and physiology and of Biomedical Engineering. Daniel Roy is currently a post-doctoral fellow at the US Army Institute of Surgical Research in San Antonio, TX.
August 15, 2015
Eric Comeau is the recipient of an American Heart Association Pre-Doctoral Fellowship. The fellowship will support Eric’s project titled “Ultrasound standing wave field technologies for cell patterning and microvessel network formation in vitro and in situ”. Through this project, Eric will advance new ultrasound technologies for tissue engineering applications. Eric is a graduate student in the Department of Biomedical Engineering and is co-mentored by Professor Diane Dalecki (BME) and Professor Denise Hocking (Pharmacology and Physiology, BME). Eric is also a student member of the Rochester Center for Biomedical Ultrasound (RCBU).
July 29, 2015
Congratulations to Steve Huntzicker who successfully defended his Ph.D. thesis titled “Quantitative Vascular Elastography: Stiffness and Stress Estimation for Identifying Rupture-Prone Plaques”. Steve’s public defense took place on Wednesday, July 29, 2015, immediately followed by a closed-door defense session. Steve has been advised by Prof. Marvin Doyley. His Ph.D. committee was chaired by Prof. Laurel Carney; other committee members were Prof. Kevin Parker, Dr. Giovanni Schifitto, and Prof. Akhtar Khan. Again, congratulations to Steve and many thanks for his hard work and significant contributions to Prof. Doyley’s Parametric Imaging Research Lab!
May 6, 2015
The latest research by Professor Diane Dalecki (BME, RCBU) and Professor Denise C. Hocking (Pharmacology & Physiology, BME, RCBU) was recognized with the Best Paper Award at the Micro- and Nanotechnology Sensors, Systems, and Applications Conference of the SPIE Defense + Security Symposium held recently in Baltimore, Maryland. Their invited paper titled “Guiding Tissue Regeneration with Ultrasound In Vitro and In Vivo” detailed three biomedical ultrasound technologies under development in their laboratories to stimulate tissue formation and regeneration. Co-authors of the paper included Sally Child, Carol Raeman, and BME graduate students Eric Comeau and Laura Hobbs. One technology under development employs forces within an ultrasound standing wave field to provide a noninvasive approach to spatially pattern endothelial cells and thereby guide the development of complex microvessel networks. A second technology uses ultrasound to site-specifically control the microstructure of collagen fibers within engineered hydrogels to direct cell function. The third line of research focuses on developing ultrasound as a therapeutic approach to enhance tissue regeneration in chronic wounds. These ultrasound technologies offer new solutions to key challenges currently facing the fields of tissue engineering, biomaterials fabrication, and regenerative medicine.
April 30, 2015
Melinda Vander Horst (BME Class 2015) presented her recent research at the 29th Annual National Undergraduate Research Conference (NCUR) held at Eastern Washington University in April. NCUR is an interdisciplinary conference where undergraduate students representing universities from around the world present their research and creative works. Melinda presented her poster, titled
Development of a dual transducer system for ultrasound standing wave field-induced particle banding, with co-authors Eric Comeau (BME graduate student), Denise C. Hocking (Pharmacology & Physiology), and Diane Dalecki (BME). Melinda is a Xerox Undergraduate Research Fellow working with Professors Dalecki and Hocking on new ultrasound technologies for tissue engineering.
April 29, 2015
BME Professor Steve McAleavey has been awarded a University of Rochester PumpPrimer II grant for his research project titled “Towards Diagnostic Ultrasonic Imaging of Tissue Non-Linearity: Strain Dependence of Shear Wave Velocity in Liver and Breast Tissue.”
March 30, 2015
Emma Grygotis was the recipient of an Outstanding Student Presentation Award at the 2015 Therapeutic Ultrasound Winter School held in Les Houches, France at the École de Physique des Houches. At this forum, held in the French Alps on March 8-13, 2015, a group of twenty professors and fifty students gathered from around the world to discuss a range of topics in the rapidly expanding field of therapeutic ultrasound. Emma presented an overview of her studies focused on developing ultrasound technologies to fabricate bioactive collagen hydrogels for wound repair.
March 30, 2015
Diane Dalecki (BME) has been elected Vice Chair of the Bioeffects Committee of the American Institute of Ultrasound in Medicine (AIUM). Professor Dalecki is a Fellow of the AIUM, and Director of the Rochester Center for Biomedical Ultrasound (RCBU). The Bioeffects Committee provides information and guidance to the AIUM on matters relating to the biological effects and safety of ultrasound. In addition to the 14 elected AIUM members, the committee includes select resource members from federal agencies and external organizations. Following completion of a 2-year term as Vice Chair, Professor Dalecki will become Chair of the Bioeffects Committee. Professor Dalecki served previously as Chair of the Bioeffects Committee from 2001-2003. The AIUM is a multidisciplinary association of more than 9000 physicians, scientists, engineers, and clinicians dedicated to advancing the safe and effective use of ultrasound in medicine.
March 25, 2015
BME seniors help real-life customers solve biomedical engineering problems through the two-semester Senior Design course taught by RCBU member Amy Lerner and Scott Seidman. In the 2014-2015 academic year, one team of BME seniors is embarking on a project to develop an ultrasound-based technique to detect dentinal cracks in teeth. The team will focus on detection of cracks in mandibular molars, as these are the teeth that exhibit cracks often. The senior design team consists of BME students Alexa Kuenstler, Jonathan Macoskey, Jacob Hyatt, Tek Gautum, and Jenny Won. Long-standing RCBU member Robert Lerner, MD who serves as the customer for this project brought the problem to the team. Diane Dalecki, Ph.D. is the senior design team supervisor for this project.
February 1, 2015
The biomedical ultrasound community sadly lost one of its important pioneers. Floyd Dunn passed away on January 24, 2015 at the age of 90. Floyd was a member of the Electrical and Computer Engineering Department at the University of Illinois at UrbanaChampaign for over 50 years. Following the death of Bill Fry in 1968, Floyd became director of the Department’s Bioacoustics Research Laboratory and made it a world leader in the field of biomedical ultrasound. Founding RCBU Director Ed Carstensen writes, “It is hard to believe today, but in the mid-1960s, research in this field had dwindled to the point that progress could be reported in biannual sessions at meetings of the Acoustical Society. Floyd and Wesley Nyborg organized those special sessions and we are uniquely indebted to them for keeping the field alive.” Floyd’s body of scientific work provides foundation for our understanding of the propagation of ultrasound in tissues and the biological effects of ultrasound. He was a member of both the National Academy of Sciences and the National Academy of Engineering, and served as President of the Acoustical Society America. He was recognized with the highest awards from numerous scientific societies, including the IEEE Edison Award, the ASA Gold and Silver Medal Awards, and the AIUM Joseph P. Holmes Basic Science Pioneer Award. He served on many FDA, NIH, AIUM, and ASA committees, and was a member of Committee 66 of the National Council on Radiation Protection. Floyd was a Charter Honorary Member of the RCBU and was a long-time friend and colleague for many of us. The RCBU and the wider biomedical ultrasound community will miss Floyd dearly.
January 13, 2015
RCBU Faculty member Marvin Doyley, Ph.D., is a part of a multidisciplinary team that was recently awarded a $3.8 million grant from the National Institutes of Health to better understand why individuals who receive anti-retroviral treatment for HIV are at greater risk for heart disease and stroke.
January 6, 2015
Marvin M. Doyley, Associate Professor of Electrical and Computer Engineering, is part of a multidisciplinary team which was recently awarded a new $3.8 million grant from the National Institutes of Health to better understand why individuals who receive anti-retroviral treatment for HIV are at greater risk for heart disease and stroke. Scientists speculate that this occurs due to some combination of the infection and treatments themselves, which may be damaging cells in the body’s blood vessels. One of the key measures in the study will be the thickness and stiffness of the carotid artery – the major blood vessel that serves the head and brain. The researchers will employ a new ultrasound technology developed by Prof. Doyley’s group to track changes to the vessel over time. UR neurologist Giovanni Schifitto is one of the principal investigators of the study, along with Sanjay Maggirwar, (UR Department of Microbiology and Immunology) and Jun-Ichi Abe (M.D. Anderson Cancer Center in Texas). Vikram Dogra (UR Imaging Sciences), Amneris Luque (UR Infections Disease Unit), and Xing Qiu (UR Biostatistics and Computational Biology) are also members of the research team. Congratulations to Prof. Doyley and the entire team!