The Eastman Medal was awarded for the first time in 2000, during the University's sesquicentennial celebration.
| Year | Recipient | Achievement | Occasion |
| 2012 | Arthur Moss | Professor of Medicine at the School of Medicine and Dentistry | SMD Commencement |
| 2011 | John H. Bruning | UR Trustee; Retired President and CEO of Corning Tropel Corporation | AS&E Commencement |
| Ursula Burns | UR Life Trustee; Chairman and Chief Executive Officer of Xerox Corporation | AS&E Commencement | |
| Eric Kandel | Director, Kavli Institute for Brain Science, Columbia University; Director, Center for Neurobiology & Behavior, New York University Medical School; 2000 Nobel Prize recipient in Physiology or Medicine | Distinguished Neuroscience Speaker Series Lecture, School of Medicine and Dentistry | |
| 2010 | William Scott Green | Sr. Vice Provost, Dean of Undergraduate Education, and Professor of Religious Studies, University of Miami | College Commencement |
| Daniel Wegman | UR Trustee; Chief Executive Officer, Wegmans Food Markets, Inc. | College Commencement | |
| 2009 | Stanley Prusiner | 1997 Nobel Laureate in Medicine; Director, Institute for Neurodegenerative Diseases and Professor of Neurology and Biochemistry, UCSF | Distinguished Neuroscience Speaker Series Lecture, School of Medicine and Dentistry |
| Louise Slaughter | Congresswoman (DNY-28) ; Chair, House Rules Committee | College Commencement | |
| Carola B. Eisenberg | Co-founder, Physicians for Human Rights; 1997 Nobel Peace Prize recipient for campaign to ban land mines | SMD Commencement | |
| William Bonnez | Development of vaccine to prevent cervical cancer | SMD Commencement | |
| Richard Reichmann | SMD Commencement | ||
| Robert Rose | SMD Commencement | ||
| 2008 | Arvid Carlsson | Professor Emeritus of Pharmacology, Göteborg University in Sweden; 2000 Nobel Prize recipient in Physiology or Medicine | Distinguished Neuroscience Speaker Series Lecture, School of Medicine and Dentistry |
| 2006 | Robert H. Hurlbut | President, Hurlbut Trust, and UR Trustee | Dr. Bradford Berk's Investiture |
| 2005 | Carl Schramm | President and CEO, Ewing Marion Kauffman Foundation | College Commencement |
| 2004 | Joseph C. Wilson '31 | Founder, Xerox Corporation | Meliora Weekend |
| 2003 | Garth Fagan | Founder and Artistic Director, Garth Fagan Dance, Inc. | Meliora Weekend |
| Ralph Snyderman, M.D. | President and CEO, Duke University Health Systems | SMD Commencement | |
| 2002 | Ted Turner | Founder, Cable News Network (CNN) | Meliora Weekend |
| 2001 | Glenda T. Lappan | Professor, Mathematics - Michigan State University | Dean Raffaella Borasi's Investiture |
| 2000 | Mark L. Schneider | Director, Peace Corps | River Campus Commencement |